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This study investigated the role of BMSCs\u2010MVs in stabilizing atherosclerotic plaques. BMSCs\u2010MVs in mice were isolated and identified. The mouse model of atherosclerosis was established, and mice were injected with BMSCs\u2010MVs via the tail vein. The macrophage model with high glucose and oxidative damage was established and then incubated with BMSCs\u2010MVs. Nod\u2010like receptor protein 3 (NLRP3) expression, pyroptosis\u2010related proteins, and inflammatory factors were detected. Actinomycin D was used to inhibit the secretion of BMSCs\u2010MVs to verify the source of microRNA\u2010223 (miR\u2010223). The binding relationship between miR\u2010223 and NLRP3 was predicted and verified. BMSCs\u2010MVs with knockdown of miR\u2010223 were cocultured with bone marrow\u2010derived macrophages\u00a0with knockdown of NLRP3, and then levels of miR\u2010223, NLRP3, pyroptosis\u2010related proteins, and inflammatory factors were detected. BMSCs\u2010MVs could reduce the vulnerability index of atherosclerotic plaques and intima\u2010media thickness in mice, and inhibit pyroptosis and inflammation. BMSCs\u2010MVs inhibited pyroptosis and inflammatory factors in macrophages. BMSCs\u2010MVs carried miR\u2010223 to inhibit NLRP3 expression and reduce macrophage pyroptosis, thereby stabilizing the atherosclerotic plaques.<\/jats:p>","DOI":"10.1002\/cbin.11526","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T07:31:00Z","timestamp":1608103860000},"page":"820-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Bone marrow\u2010derived mesenchymal stem cells microvesicles stabilize atherosclerotic plaques by inhibiting NLRP3\u2010mediated macrophage pyroptosis"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8545-3257","authenticated-orcid":false,"given":"Yu","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Renji Hospital, School of Medicine, Shanghai Jiaotong University  Shanghai 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