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Seconded, knockdown of Girdin significantly suppressed EOC cell viability, migration, and invasion, while upregulation of Girdin produced the opposite effects in vitro and facilitated lung metastasis in EOC cell xenograft in vivo. In addition, we confirmed that the inhibitory effect of Metformin on Girdin expression. Mechanistically, the oncogenic effects of Girdin could be reversed by LY294002 (an AKT pathway inhibitor) and Metformin. These results suggested that Metformin attenuated EOC metastasis through Girdin and targeting Girdin may be a promising therapeutic strategy for EOC in the future.<\/jats:p>","DOI":"10.1002\/cbin.11547","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T19:03:28Z","timestamp":1610046208000},"page":"1030-1037","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Roles of metformin\u2010mediated girdin expression in metastasis of epithelial ovarian cancer"],"prefix":"10.1002","volume":"45","author":[{"given":"Jianhong","family":"Dang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Changzheng Hospital The Naval Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghai","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Changzheng Hospital The 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