{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:37:55Z","timestamp":1758634675111,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>MiR\u2010370\u20103p has been demonstrated to be downregulated in patients with endometriosis (EM). However, its role and molecular mechanisms in the progression of EM remain unclear. Real\u2010time polymerase chain reaction was used to measure the expression of miR\u2010370\u20103p and endothelin\u20101 (EDN1) in patients with or without EM. After miR\u2010370\u20103p overexpression or knockdown in ectopic endometrial hEM15A cells, the changes in the proliferation, apoptosis, and migration and invasion capacities were detected by using cell counting kit\u20108, flow cytometry, and transwell methods. The interplay between miR\u2010370\u20103p and EDN1\u00a0was confirmed by a luciferase reporter assay. Patients with EM showed adverse expression of EDN1 and miR\u2010370\u20103p, especially in eutopic endometrium\u00a0and ectopic endometrium. MiR\u2010370\u20103p inhibited the proliferation, metastasis, and invasion capacities of hEM15A cells\u00a0and promoted apoptosis. Investigation of\u00a0its molecular mechanism revealed that miR\u2010370\u20103p targeted EDN1 to influence the biological functions of hEM15A cells. MiR\u2010370\u20103p represented as a therapeutic target for EM treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbin.11552","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T13:37:09Z","timestamp":1611149829000},"page":"1183-1190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["MiR\u2010370\u20103p inhibits the development of human endometriosis by downregulating EDN1 expression in endometrial stromal cells"],"prefix":"10.1002","volume":"45","author":[{"given":"Shun","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology, Women's Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Women's Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Women's Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4333-9533","authenticated-orcid":false,"given":"Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women's Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56760-0"},{"issue":"5","key":"e_1_2_10_3_1","first-page":"447","article-title":"Update on endometriosis pathogenesis","volume":"69","author":"Czyzyk A.","year":"2017","journal-title":"Minerva Ginecologica"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.893872"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018067"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13179"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-016-0836-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00244.2018"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S217795"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S149908"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0706-z"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.08.034"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12577"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1599089"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy014"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.04.066"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-17-0092"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123789"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6269-x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/XST-17286"},{"issue":"9","key":"e_1_2_10_21_1","first-page":"2027","article-title":"Regulation of miR\u201033b on endometriosis and expression of related factors","volume":"21","author":"Yang W. 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