{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:36:44Z","timestamp":1740105404122,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971421","and 81471485"],"award-info":[{"award-number":["81971421","and 81471485"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017ZZ02019"],"award-info":[{"award-number":["2017ZZ02019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mental retardation is the main clinical manifestation of Down syndrome (DS), and neural abnormalities occur during the\u00a0early embryonic period and continue throughout life. Tc1, a model mouse for DS, carries the majority part of the human chromosome 21 and has multiple neuropathy phenotypes similar to patients with DS. To explore the mechanism of early neural abnormalities of Tc1 mouse, induced pluripotent stem (iPS) cells from Tc1 mice\u00a0were obtained, and genome\u2010wide gene expression and methylation analysis were performed for Tc1 and wild\u2010type iPS cells. Our results showed hypermethylation profiles for Tc1 iPS cells, and the abnormal genes were shown to be related to neurodevelopment and distributed on multiple chromosomes. In addition, important genes involved in neurogenesis and neurodevelopment were shown to be downregulated in Tc1 iPS cells. In short, our study indicated that genome\u2010wide hypermethylation leads to the disordered expression of genes associated with neurodevelopment in Tc1 mice during early development. Overall, our work provided a useful reference for the study of the molecular mechanism of nervous system abnormalities in DS.<\/jats:p>","DOI":"10.1002\/cbin.11560","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T23:00:41Z","timestamp":1612393241000},"page":"1383-1392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome\u2010wide hypermethylation is closely associated with abnormal expression of genes involved in neural development in induced pluripotent stem cells derived from a Down syndrome mouse model"],"prefix":"10.1002","volume":"45","author":[{"given":"Jiao\u2010jiao","family":"Xi","sequence":"first","affiliation":[{"name":"Shanghai Institute of Medical Genetics, Shanghai Children's Hospital Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan\u2010heng","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Medical Genetics, Shanghai Children's Hospital Shanghai Jiao Tong University Shanghai China"},{"name":"NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology &amp; Shanghai Key Laboratory of Embryo and Reproduction Engineering Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010na","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Medical Genetics, Shanghai Children's Hospital Shanghai Jiao Tong University Shanghai China"},{"name":"NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology &amp; Shanghai Key Laboratory of Embryo and Reproduction Engineering Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010jun","family":"Qiu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Medical Genetics, Shanghai Children's Hospital Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu\u2010li","family":"Gong","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Medical Genetics, Shanghai Children's Hospital Shanghai Jiao Tong University Shanghai China"},{"name":"NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology &amp; Shanghai Key Laboratory of Embryo and Reproduction Engineering Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010bin","family":"Yan","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Medical Genetics, Shanghai Children's Hospital Shanghai Jiao Tong University Shanghai China"},{"name":"NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology &amp; Shanghai Key Laboratory of Embryo and Reproduction Engineering Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7053-1614","authenticated-orcid":false,"given":"Fanyi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Medical Genetics, Shanghai Children's Hospital Shanghai Jiao Tong University Shanghai China"},{"name":"NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology &amp; Shanghai Key Laboratory of Embryo and Reproduction Engineering Shanghai China"},{"name":"Department of Histoembryology, Genetics and Development Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.5.613-a"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1297"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-612-8_17"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-013-0089-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12745"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2016.1192736"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2016.02.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-321"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.91"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr167"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2019.1609867"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2017.1311434"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1237905"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/23262133.2017.1313646"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5375"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21722"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29835"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1114535"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10202"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.418"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp120"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-2-r14"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08267"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbin.11560","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:48:39Z","timestamp":1693201719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.11560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,23]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/cbin.11560"],"URL":"https:\/\/doi.org\/10.1002\/cbin.11560","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"type":"print","value":"1065-6995"},{"type":"electronic","value":"1095-8355"}],"subject":[],"published":{"date-parts":[[2021,4,23]]},"assertion":[{"value":"2020-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}