{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:46:19Z","timestamp":1779309979019,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A030313669"],"award-info":[{"award-number":["2018A030313669"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>One hallmark of renal cell carcinoma (RCC) is metabolic reprogramming, which involves elevation of glycolysis and upregulation of lipid metabolism. However, the mechanism of metabolic reprogramming is incompletely understood. Monocarboxylate transporter 1 (MCT1) promotes transport for lactate and pyruvate, which are crucial for cell metabolism. The aim of present study was to investigate the function of MCT1 on RCC development and its mechanism on metabolic reprogramming. The results showed that MCT1 messenger RNA and protein levels significantly increased in cancer tissues of ccRCC compared to normal tissue. MCT1 was further found to mainly located in the cell membrane of RCC. The knockdown of MCT1 by RNAi significantly inhibited proliferation and migration of 786\u2010O and ACHN cells. MCT1 also induced the expressions of proliferation marker Ki\u201067 and invasion marker SNAI1. Moreover, we also showed that acetate treatment could upregulate the expression of MCT1, but not other MCT isoforms. On the other hand, MCT1 was involved in acetate transport and intracellular histone acetylation. In summary, this study revealed that MCT1 is abnormally high in ccRCC and promotes cancer development. The regulatory effect of MCT1 on cell proliferation and invasion maybe mediated by acetate transport.<\/jats:p>","DOI":"10.1002\/cbin.11571","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T05:11:36Z","timestamp":1612933896000},"page":"1278-1287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Monocarboxylate transporter 1 promotes proliferation and invasion of renal cancer cells by mediating acetate transport"],"prefix":"10.1002","volume":"45","author":[{"given":"Minghua","family":"Li","sequence":"first","affiliation":[{"name":"Central Laboratory Peking University Shenzhen Hospital Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Long","sequence":"additional","affiliation":[{"name":"Central Laboratory Peking University Shenzhen Hospital Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Wan","sequence":"additional","affiliation":[{"name":"Central Laboratory Peking University Shenzhen Hospital Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meijun","family":"Yin","sequence":"additional","affiliation":[{"name":"Central Laboratory Peking University Shenzhen Hospital Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology Peking University Shenzhen Hospital, Shenzhen PKU\u2010HKUST Medical Center Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Central Laboratory Peking University Shenzhen Hospital Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1068-5926","authenticated-orcid":false,"given":"Xiaoqiang","family":"Guo","sequence":"additional","affiliation":[{"name":"Central Laboratory Peking University Shenzhen Hospital Shenzhen Guangdong China"},{"name":"Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology Peking University Shenzhen Hospital, Shenzhen PKU\u2010HKUST Medical Center Shenzhen Guangdong China"},{"name":"Xiaobei Medical Research Institute, Department of Physical Education Shijiazhuang Vocational College of Technology Shijiazhuang Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"issue":"10","key":"e_1_2_12_2_1","first-page":"1029","article-title":"MCT1\/4 and CD147 overexpression supports the metabolic reprogramming in papillary renal cell carcinoma","volume":"32","author":"Almeida L. M. C. A.","year":"2017","journal-title":"Histology and Histopathology"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193477"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2014.194"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-2474"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.055"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002394"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.03.031"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000178"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1600200"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69741"},{"issue":"5","key":"e_1_2_12_12_1","first-page":"1016","article-title":"Revisiting the hallmarks of cancer","volume":"7","author":"Fouad Y. A.","year":"2017","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11960"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90361-1"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-019-0889-8"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-003-1067-2"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.572"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.01.057"},{"issue":"5","key":"e_1_2_12_20_1","first-page":"1007","article-title":"Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells","volume":"102","author":"Izumi H.","year":"2011","journal-title":"Cancer Prevention Research"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25305"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3727\/096504017X14902648894463"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000104"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.09.013"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000571"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12907-017-0067-7"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.04.026"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.30"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2012.06.002"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2010.47"},{"issue":"69","key":"e_1_2_12_31_1","first-page":"e1","article-title":"Snail predicts recurrence and survival of patients with localized clear cell renal cell carcinoma after surgical resection","volume":"33","author":"Liu W.","year":"2015","journal-title":"Urologic Oncology"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.07.002"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos298"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.9.1.75"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1309\/HV6NJVRQKK4QHM9F"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.12.006"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-0764"},{"issue":"1","key":"e_1_2_12_38_1","first-page":"1","article-title":"Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti\u2010cancer therapies","volume":"11","author":"Phan L. M.","year":"2014","journal-title":"Cancer Biology & Medicine"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-012-9428-1"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2018.06.003"},{"issue":"2","key":"e_1_2_12_41_1","first-page":"119","article-title":"Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect","volume":"38","author":"San\u2010Mill\u00e1n I.","year":"2017","journal-title":"Carcinogenesis"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.87"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-007-9081-2"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"issue":"3","key":"e_1_2_12_45_1","first-page":"275","article-title":"Cancer metabolism: key players in metabolic reprogramming","volume":"104","author":"Soga T.","year":"2013","journal-title":"Cancer Prevention Research"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2019.01.006"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00651"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.26193"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-196"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.59"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44281"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487293"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.08.042"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11571","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbin.11571","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T22:16:17Z","timestamp":1693606577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.11571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,19]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/cbin.11571"],"URL":"https:\/\/doi.org\/10.1002\/cbin.11571","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,19]]},"assertion":[{"value":"2020-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}