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However, long\u2010term, poor bonding with bone, corrosion, and release of metal ions, such as chromium\u00a0and nickel occur. These ions are powerful allergens and carcinogens and their uncontrolled leaching may be avoided by surface coatings. Therefore, bioactive glasses (BGs) became a vital biomedical material, which can form a biologically active phase of hydroxycarbonate apatite on their surface when in contact with physiological fluids. To reduce the high coefficient of friction and the brittle nature of BGs, polymers are normally incorporated to avoid the high\u2010temperature sintering\/densification of ceramic\u2010only coatings. For medical application, electrophoretic deposition (EPD) is now used for polymer (organic) and ceramic (inorganic) components at room temperature due to its simplicity, control of coating thickness and uniformity, low cost of equipment, ability to coat substrates of intricate shape and to supply thick films in composite form, high purity of deposits as well as no phase transformation during coating. Although extensive research has been conducted on polymer\/inorganic composite coatings, only some studies have reported multifunctional properties, such as biological antibacterial activity, enhanced cell adhesion, controlled drug release ability, and mechanical properties. This review will focus on biodegradable coatings, including zien, chitosan, gelatin, cellulose loaded with antibacterial drugs\/metallic ions\/natural herbs on biostable substrates (PEEK\/PMMA\/PCL\/PLLA layers), which have the potential of multifunctional coating for metallic implants.<\/jats:p>","DOI":"10.1002\/cbin.11604","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T10:39:36Z","timestamp":1617619176000},"page":"1624-1632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Biosensitive and antibacterial coatings on metallic material for medical applications"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0738-2665","authenticated-orcid":false,"given":"Wolfgang H.","family":"Goldmann","sequence":"first","affiliation":[{"name":"Department of Biophysics Friedrich\u2010Alexander\u2010University of Erlangen\u2010Nuremberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2015.06.003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.72B6.2246300"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.05.031"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111062"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2015.11.075"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surfcoat.2019.125138"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3305-1_26"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2006.07.001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2010.0156.focus"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10853-006-0556-z"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-12460-5_7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.07.089"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.03.019"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-53980-0_16"},{"key":"e_1_2_10_16_1","first-page":"1","article-title":"Fabrication and characterization of Ag and Ga\u2010doped mesoporous glass\u2010coated scaffolds with improved mechanical properties based on natural marine sponges","author":"Ciraldo F. 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