{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:36:36Z","timestamp":1774330596526,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301052"],"award-info":[{"award-number":["81301052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2042020gf0010, 2042020kf0054"],"award-info":[{"award-number":["2042020gf0010, 2042020kf0054"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The nerve conduits have been developed for nerve defect repair. However, no artificial conduits have obtained comparable results to autografts to bridge the large gaps. A possible reason for this poor performance may be a lack of sustainable neurotrophic support for axonal regrowth. Previous studies suggested nanocomposite conduits can be used as a carrier for valproic acid (VPA), a common drug that can produce effects similar to the neurotrophic factors. Here, we developed the novel bioabsorbable conduits based on hydroxyapatite\/poly <jats:sc>d<\/jats:sc>\u2010<jats:sc>l<\/jats:sc>\u2010lactic acid (PDLLA)\/poly{(lactic acid)\u2010co\u2010[(glycolic acid)\u2010alt\u2010(<jats:sc>l<\/jats:sc>\u2010lysine)]} with sustained release of VPA. Firstly, the sustained release of VPA in this conduit was examined by high\u2010performance liquid chromatography. Then Schwann cells were treated with the conduit extracts. The cell metabolic activity and proliferation were assayed by 3\u2010[4,5\u2010dimethyl\u20102\u2010thiazolyl]\u20102,5\u2010diphenyl\u20102\u2010tetrazolium bromide and bromodeoxyuridine staining. A 10\u2010mm segment of rat sciatic nerve was resected and then repaired, respectively, using the VPA conduit (Group A), the PDLLA conduit (Group B), or the autografts (Group C). Nerve conduction velocities (NCVs), compound muscle action potentials (CMAPs), and histological staining were assayed following the surgery. The cell metabolic activity and proliferation were significantly increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) by the extracts from VPA\u2010conduit extract compared to others. NCVs and CMAPs were significantly higher in Groups A and C than Group B (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The nerve density of Groups A and C was higher than Group B. There was no significant difference between Groups A and C. Taken together, this study suggested the sustained\u2010release VPA conduit promoted peripheral nerve regeneration that was comparable to the autografts. It holds potential for future use in nerve regeneration.<\/jats:p>","DOI":"10.1002\/cbin.11613","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:37:40Z","timestamp":1618447060000},"page":"1733-1742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Nerve conduit based on HAP\/PDLLA\/PRGD for peripheral nerve regeneration with sustained release of valproic acid"],"prefix":"10.1002","volume":"45","author":[{"given":"Fei","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Renmin Hospital Wuhan University  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanjie","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics \u00a0Yangxin People's Hospital  Huangshi Hubei 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