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One hundred patients with non\u2010small cell lung cancer (NSCLC) were divided into MiniPDX group and conventional group, with 50 cases in each group. The MiniPDX assay was established by enriching high\u2010purity tumor cells using microfluidic technology to detect the drug sensitivity of NSCLC cells. All patients underwent conventional computed tomography (CT) scans of lung and mediastinum at baseline and during follow\u2010up. Kaplan\u2013Meier method was used to compare the overall survival and progression\u2010free survival of two groups. The sensitivity of the same drug in different tumor xenograft varied greatly. The overall survival, progression\u2010free survival, and clinical benefit rate of patients in the MiniPDX\u2010guided chemotherapy group were significantly longer than those in the conventional chemotherapy group. 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