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This is not the first nor will it be the last time that a member of \u03b2\u2010coronaviruses (CoVs) is waging a full\u2010scale war against human health. Notwithstanding the fact that pneumonia is the primary symptom of the novel coronavirus (2019nCoV; designated as SARS\u2010CoV\u20102), the emergence of severe disease mainly due to the injury of nonpulmonary organs at the shadow of coagulopathy leaves no choice, in some cases, rather than a dreadful death. Multiple casual factors such as inflammation, endothelial dysfunction, platelet and complement activation, renin\u2010angiotensin\u2010aldosterone system derangement, and hypoxemia play a major role in the pathogenesis of coagulopathy in coronavirus disease 2019 (COVID\u201019) patients. Due to the undeniable role of coagulation dysfunction in the initiation of several complications, assessment of coagulation parameters and the platelet count would be beneficial in early diagnosis and also timely prediction of disease severity. Although low\u2010molecular\u2010weight heparin is considered as the first\u2010line of treatment in COVID\u201019\u2010associated coagulopathy, several possible therapeutic options have also been proposed for better management of the disease. In conclusion, this review would help us to gain insight into the pathogenesis, clinical manifestation, and laboratory findings associated with COVID\u201019 coagulopathy and would summarize management strategies to alleviate coagulopathy\u2010related complications.<\/jats:p>","DOI":"10.1002\/cbin.11623","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T12:39:16Z","timestamp":1620131956000},"page":"1832-1850","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["COVID\u201019\u2010related coagulopathy: A review of pathophysiology and pharmaceutical management"],"prefix":"10.1002","volume":"45","author":[{"given":"Mahdi","family":"Kohansal Vajari","sequence":"first","affiliation":[{"name":"Department of Hematology and Blood Banking, School of Allied Medical Sciences Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Shirin","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Banking, School of Allied Medical Sciences Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atieh","family":"Pourbagheri\u2010Sigaroodi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Banking, School of Allied Medical Sciences Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Esmaeil","family":"Akbari","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Department of General Surgery Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Abolghasemi","sequence":"additional","affiliation":[{"name":"Pediatric Congenital Hematologic Disorders Research Center, Mofid Hospital Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8029-4920","authenticated-orcid":false,"given":"Davood","family":"Bashash","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Banking, School of Allied Medical Sciences Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,16]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","article-title":"The Prognostic value of thrombocytopenia in COVID\u201019 patients: A systematic review and meta\u2010analysis","volume":"8","author":"Bashash D.","year":"2020","journal-title":"Archives of Academic Emergency Medicine"},{"key":"e_1_2_10_3_1","unstructured":"Bashash D. 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