{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:34:43Z","timestamp":1776094483213,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hepatoblastoma (HB) is the predominant hepatic neoplasm in infants and young children. Sorafenib has been used to treat adult and pediatric hepatocellular carcinoma. However, efficacy of monotherapy of sorafenib in HB is not sustained. In this study, we tested a possible combinatory therapy of sorafenib with the CCAAT\/enhancer\u2010binding proteins (C\/EBP) overexpression in HB cell line. Firstly, we evaluated the expression level of C\/EBP\u03b2 in the patients with HB by analyzing The Cancer Genome Atlas data. Lower level of C\/EBP\u03b2 was observed in tumor tissues in comparison with matched normal tissues. Next, we observed that combination of sorafenib and C\/EBP\u03b2 overexpression led to dramatic growth and migration inhibition of live tumor cells which implied promising probability for clinical trial. Mechanistically, C\/EBP\u03b2 which can be downregulated by Ras v12, augmented messenger RNA and protein levels of p53. These data suggested that a combination of sorafenib and C\/EBP\u03b2 overexpression inhibited tumor growth synergistically and provided a promising approach to treat HB.<\/jats:p>","DOI":"10.1002\/cbin.11624","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T12:37:10Z","timestamp":1620131830000},"page":"1897-1905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["C\/EBP\u03b2 enhances efficacy of sorafenib in hepatoblastoma"],"prefix":"10.1002","volume":"45","author":[{"given":"Chong","family":"Pang","sequence":"first","affiliation":[{"name":"Departments of Pharmacology Chengde Medical University  Chengde Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Miao","sequence":"additional","affiliation":[{"name":"Functional Experiment Center Chengde Medical University  Chengde Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanzhen","family":"Zuo","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology Chengde Medical University  Chengde Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Guo","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology Chengde Medical University  Chengde Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayong","family":"Sun","sequence":"additional","affiliation":[{"name":"Tumor Radiation and Chemotherapy Center Chengde Central Hospital  Chengde Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoqun","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology Chengde Medical University  Chengde Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1672"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(05)07047-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.008152"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.14.4841-4858.2003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24268"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2016.10.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.06.102"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02729.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.539"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22893"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2011.03.011"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/11595360-000000000-00000"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1249"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.06.155"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0011"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708857"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.33156"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2014.10.018"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201000004"},{"key":"e_1_2_10_21_1","first-page":"2498","article-title":"Sorafenib in advanced hepatocellular carcinoma","volume":"359","author":"Palmer D. H.","year":"2008","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1093526619875228"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2005.04.004"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-12-162"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-0414"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23295"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M701329200"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.2165\/11596690-000000000-00000"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2613.1998.00082.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124308"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.03.006"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.062146aw"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-3006"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2016.02.492"}],"updated-by":[{"DOI":"10.1002\/cbin.70128","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000}}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11624","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbin.11624","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T09:55:58Z","timestamp":1770198958000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.11624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,18]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/cbin.11624"],"URL":"https:\/\/doi.org\/10.1002\/cbin.11624","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,18]]},"assertion":[{"value":"2021-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}