{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T22:59:28Z","timestamp":1770245968065,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In the treatment of cardiovascular diseases, vascular scaffold materials play an extremely important role. The appropriate substrate chemistries and 15 dynes\/cm\n                    <jats:sup>2<\/jats:sup>\n                    physiological fluid shear stress (FSS) are both required to ensure normal physiological activity of human umbilical vein endothelial cells (HUVECs). The present study reported the collective influence of substrate chemistries and FSS on HUVECs in the sense of its biological functions. The CH\n                    <jats:sub>3<\/jats:sub>\n                    , NH\n                    <jats:sub>2<\/jats:sub>\n                    , and OH functional groups were adopted to offer a variety of substrate chemistries on glass slides by the technology of self\u2010assembled monolayers, whereas FSS was generated by a parallel\u2010plate fluid flow system. Substrate chemistries on its own by no means had noticeable effects on eNOS, ATP, NO, and PGI\n                    <jats:sub>2<\/jats:sub>\n                    expressions, while FSS stimuli enhanced their production. While substrate chemistries, as well as FSS, were both exerted, the releases of ATP, NO, and PGI\n                    <jats:sub>2<\/jats:sub>\n                    were dependent on substrate chemistries. Study of F\u2010actin organization and focal adhesions (FAs) formation of HUVECs before FSS exposure proves that F\u2010action organization and FAs formation followed similar chemistry\u2010dependence. Hereby proposed a feasible mechanism, that is, the F\u2010actin organization and FAs formation of HUVECs are controlled by substrate chemistries, further advancing the modulation of FSS\u2010triggered responses of HUVECs.\n                  <\/jats:p>","DOI":"10.1002\/cbin.11632","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T12:46:54Z","timestamp":1621428414000},"page":"1926-1934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Collective influence of substrate chemistry with physiological fluid shear stress on human umbilical vein endothelial cells"],"prefix":"10.1002","volume":"45","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmacy Taizhou Polytechnic College  Taizhou China"},{"name":"Bone Tissue Engineering Research Center of Taizhou  Taizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5849-3010","authenticated-orcid":false,"given":"Zhongjie","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The Affiliated Stomatology Hospital of South\u2010west Medical University  Luzhou China"},{"name":"Orofacial Reconstruction and Regeneration, Laboratory The Affiliated Stomatology Hospital of Southwest Medical University  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmacy Taizhou Polytechnic College  Taizhou China"},{"name":"Bone Tissue Engineering Research Center of Taizhou  Taizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3798-5301","authenticated-orcid":false,"given":"Khawar Ali","family":"Shahzad","sequence":"additional","affiliation":[{"name":"School of Pharmacy Taizhou Polytechnic College  Taizhou China"},{"name":"Department of Zoology The Islamia University of Bahawalpur  Bahawalpur Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delin","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The Affiliated Stomatology Hospital of South\u2010west Medical University  Luzhou China"},{"name":"Orofacial Reconstruction and Regeneration, Laboratory The Affiliated Stomatology Hospital of Southwest Medical University  Luzhou China"},{"name":"Plastic and Maxillofacial Surgery Department Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.03.013"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/la00016a041"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","unstructured":"Boespflug G. Maire M. Crescenzo G. D. Lerouge S. &Wertheimer M. R.(2017).Characterization and comparison of N\u2010 O\u2010 and N+O\u2010functionalized polymer surfaces for efficient (HUVEC) endothelial cell colonization.Plasma Processes and Polymers.","DOI":"10.1002\/ppap.201600139"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12361"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2017.0088"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-018-1076-x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4LC01236D"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.08.012"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1431927617012454"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8IB00032H"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35233"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2014.12.023"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2018.11.039"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-015-0647-3"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2004.09.030"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.04.089"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.109.4.713"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1114\/1.173"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.10.028"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00035.2016"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1516247112"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.10.002"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.03.056"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00241.2015"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11632","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbin.11632","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T09:55:41Z","timestamp":1770198941000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.11632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,9]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/cbin.11632"],"URL":"https:\/\/doi.org\/10.1002\/cbin.11632","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,9]]},"assertion":[{"value":"2020-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}