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In this study, we detected the abnormal expression of circular RNA (circRNA) using next\u2010generation sequencing in patients with MG. We then investigated the regulatory mechanism and the relationship among circRNA, microRNA, and messenger RNA using quantitative reverse\u2010transcription polymerase chain reaction, bioinformatics analysis, and luciferase report analysis. The expression of inflammatory cytokines and regulatory T lymphocytes was shown to be increased. Circ\u2010FBL was significantly increased in MG patients. Bioinformatics and luciferase report analyses confirmed that miR\u2010133 and PAX7 were the downstream targets of circ\u2010FBL. Overexpression of circ\u2010FBL promoted myoblast proliferation by regulation of miR\u2010133\/PAX7. Taken together, our study showed that upregulation of circ\u2010FBL promoted myogenic proliferation in patients with MG by regulating miR\u2010133\/PAX7.<\/jats:p>","DOI":"10.1002\/cbin.11676","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T08:37:25Z","timestamp":1628325445000},"page":"2287-2293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Upregulation of circ\u2010FBL promotes myogenic proliferation in myasthenia gravis by regulation of miR\u2010133\/PAX7"],"prefix":"10.1002","volume":"45","author":[{"given":"Xiaoyin","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Neurology Gongli Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuajin","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology 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