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Interferon regulatory factors (IRF) are key players in chronic cardiac disorders such as cardiac remodeling. However, their roles in acute MIR injury remain largely unknown. In the current study, microarray data indicated that IRF1 expression was consistently changed in the human ischemic heart and ischemic reperfused mouse heart. Western blot analysis confirmed the expression alterations of IRF1 in ischemic reperfused mouse heart. Cardiac\u2010specific IRF1 knockdown significantly decreased infarct size, improved cardiac function, and suppressed myocardial apoptosis after MIR injury. Conversely, cardiac\u2010specific IRF1 overexpression significantly promoted MIR injury. Further investigation revealed that IRF1 transcriptionally regulated the expression of inducible nitric oxide synthase (iNOS), and augmented oxidative stress. Taken together, we presented the first direct evidence that IRF1 served as a mediator of MIR injury, and IRF1 may represent a potential therapeutic target for alleviating MIR injury.<\/jats:p>","DOI":"10.1002\/cbin.11713","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T02:46:59Z","timestamp":1634698019000},"page":"63-72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The transcription factor interferon regulatory factor\u20101 is an endogenous mediator of myocardial ischemia reperfusion injury"],"prefix":"10.1002","volume":"46","author":[{"given":"Wenlong","family":"Jiang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Oncogenes and Related Genes, Division of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai Cancer Institute Shanghai 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