{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T09:29:18Z","timestamp":1786786158859,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Currently, the prevention of ischemic diseases such as myocardial infarction associated with ischemia\/reperfusion (I\/R) injury remains to be a challenge. Thus, this study was designed to explore the effects of tripartite motif protein 11 (TRIM11) on cardiomyocytes I\/R injury and its underlying mechanism.\u00a0Cardiomyocytes AC16 were used to establish an I\/R injury cell model. After TRIM11 downregulation in I\/R cells, cell proliferation (0, 12, 24, and 48\u2009h) and apoptosis at 48\u2009h as well as the related molecular changes in oxidative stress\u2010related pathways was detected. Further, after the treatment of TRIM11 overexpression, SP600125, or DUSP1 overexpression, cell proliferation, apoptosis, and related genes were detected again.\u00a0As per our findings, it was determined that TRIM11 was highly expressed in the cardiomyocytes AC16 after I\/R injury. Downregulation of TRIM11 was determined to have significantly reduced I\/R\u2010induced proliferation suppression and apoptosis. Besides, I\/R\u2010activated c\u2010Jun N\u2010terminal kinase (JNK) signaling and cleaved caspase 3 and Bax expression were significantly inhibited by TRIM11 downregulation. In addition, the overexpression of TRIM11 significantly promoted apoptosis in AC16 cells, and JNK1\/2 inhibition and DUSP1 overexpression potently counteracted the induction of TRIM11 overexpression in AC16 cells.\u00a0These suggested that the downregulation of TRIM11 attenuates apoptosis in AC16 cells after I\/R injury probably through the DUSP1\u2010JNK1\/2 pathways.<\/jats:p>","DOI":"10.1002\/cbin.11716","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T05:05:35Z","timestamp":1635138335000},"page":"148-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["RETRACTED: Downregulation of tripartite motif protein 11 attenuates cardiomyocyte apoptosis after ischemia\/reperfusion injury via DUSP1\u2010JNK1\/2"],"prefix":"10.1002","volume":"46","author":[{"given":"Fang","family":"He","sequence":"first","affiliation":[{"name":"Shanghai Changning Mental Health Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheqian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Emergency Shidong Hospital of Yangpu District Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Shidong Hospital of Yangpu District Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Emergency Shidong Hospital of Yangpu District Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Emergency Shidong Hospital of Yangpu District Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Emergency Shidong Hospital of Yangpu District Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.09.031"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.11.004"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-14-32"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/23723556.2014.997518"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1982"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-017-0423-5"},{"key":"e_1_2_12_8_1","first-page":"2567","article-title":"Tripartite motif\u2011containing 11 regulates the proliferation and apoptosis of breast cancer cells","volume":"41","author":"Dai X.","year":"2019","journal-title":"Oncology Reports"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.301"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.531"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010755"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.2.5.9441"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.05.065"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2017.01.002"},{"key":"e_1_2_12_15_1","first-page":"935","article-title":"Targeting reperfusion injury in patients with ST\u2010segment elevation myocardial infarction: Trials and tribulations","volume":"38","author":"Hausenloy D. 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