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MicroRNAs (miRs) serve imperative roles in the regulation of many biological processes of hair follicles. However, the exact molecular mechanism of AGA remains to be elucidated. In the present study, we found miR\u2010122, which is mainly recognized as a tumor suppressor, was highly overexpressed in the bulb of balding hair follicles in comparison with nonbalding ones in AGA. Moreover, miR\u2010122 induces apoptosis of human dermal papilla cells (hDPCs) with miR\u2010122 mimics in vitro, and the expression of insulin\u2010like growth factor 1 receptor (IGF1R) in hDPCs was reduced following upregulation of miR\u2010122. Mechanistically, dual\u2010luciferase reporter assay confirmed that miR\u2010122 directly targeted the 3\u2032\u2010untranslated region of IGF1R. These findings suggested that upregulation of miR\u2010122 induces apoptosis, potentially via the repression of IGF1R in hDPCs of AGA, providing a novel insight into the potential pathological mechanism of miR\u2010122 in AGA DPCs.<\/jats:p>","DOI":"10.1002\/cbin.11723","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T10:19:09Z","timestamp":1636366749000},"page":"185-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Overexpression of miR\u2010122 promotes apoptosis of dermal papilla cells by directly targeting IGF1R in androgenetic alopecia"],"prefix":"10.1002","volume":"46","author":[{"given":"Ye","family":"He","sequence":"first","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery Nanfang Hospital of Southern Medical University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery Nanfang Hospital of Southern Medical University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery Nanfang Hospital of Southern Medical University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery Nanfang Hospital of Southern Medical University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhexiang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery Nanfang Hospital of Southern Medical University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Decong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery Nanfang Hospital of Southern Medical University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery Nanfang Hospital of Southern Medical University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-6187","authenticated-orcid":false,"given":"Zhiqi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery Nanfang Hospital of Southern Medical University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1825"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.1.26"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.785"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.426"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.016774"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(05)80085-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.033977.112"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02937.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-009-9862-2"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12024"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-160663"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2013.0547"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2013.04.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12339"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10514.x"},{"issue":"1","key":"e_1_2_8_17_1","first-page":"79","article-title":"Oxidative stress in androgenetic alopecia","volume":"9","author":"Prie B. 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