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Interleukin\u201017 (IL\u201017), also named IL\u201017A, is a critical signature cytokine of T\u2010helper 17 cells. Upon binding to the IL\u201017 receptor A\/C heterodimeric complex, IL\u201017 can trigger multiple signal transduction pathways to stimulate gene transcription and increase messenger RNA stability. IL\u201017 expression is significantly increased in degenerative disc tissue and shows a positive correlation with disease severity. IL\u201017 has been shown to accelerate the development of IDD by promoting extracellular matrix degradation, enhancing inflammatory response, inducing neoangiogenesis, and inhibiting nucleus pulposus cell autophagy and proliferation. Targeting IL\u201017 represents a novel and promising approach for the therapeutic intervention of IDD. In this review, we summarized the recent progression about the role of IL\u201017 in IDD and highlighted its therapeutic implications.<\/jats:p>","DOI":"10.1002\/cbin.11767","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T20:17:46Z","timestamp":1642969066000},"page":"535-547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["IL\u201017 in intervertebral disc degeneration: Mechanistic insights and therapeutic implications"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-3701","authenticated-orcid":false,"given":"Jing\u2010Hua","family":"Tan","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital, Department of Spine Surgery, Hengyang Medical School University of South China Hengyang Hunan 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