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Since telomere\/telomerase dysfunction is involved in myocardial ischemic damage, the present study aimed to investigate whether Dex ameliorates cobalt chloride (CoCl<jats:sub>2;<\/jats:sub> a hypoxia mimic agent in vitro)\u2010induced the damage of H9c2 cardiomyocytes by improving telomere\/telomerase dysfunction and further explored the underlying mechanism focusing on extracellular signal\u2010regulated kinase (ERK1\/2)\u2010NF\u2010E2\u2010related factor 2 (Nrf2) signaling pathway. The result showed that Dex increased cell viability, decreased apoptosis, and reduced cardiomyocyte hypertrophy as illustrated by the decreases in cell surface area and the biomarker levels for cardiac hypertrophy including atrial natriuretic peptide, brain natriuretic peptide, and myosin heavy chain \u03b2 messenger RNA (mRNA) and protein in CoCl<jats:sub>2<\/jats:sub>\u2010exposed H9c2 cells. Intriguingly, Dex increased the telomere length and telomerase activity as well as telomere reverse transcriptase protein and mRNA levels in H9c2 cells exposed to CoCl<jats:sub>2<\/jats:sub>, indicating that Dex promotes telomere\/telomerase function under hypoxia. In addition, Dex remarkably diminished the reactive oxygen species generation, reduced malondialdehyde content, and increased antioxidative signaling as evidenced by the increases in superoxide dismutase and plasma glutathione peroxidase activities. Furthermore, Dex increased the ratio of P\u2010ERK1\/2\/T\u2010ERK1\/2 and P\u2010Nrf2\/T\u2010Nrf2 and enhanced Nrf2 nuclear translocation in CoCl<jats:sub>2<\/jats:sub>\u2010subjected H9c2 cells, suggesting that Dex promotes the activation of the ERK1\/2\u2010Nrf2 signaling pathway. These novel findings indicated that Dex attenuates myocardial ischemic damage and reduces myocardial hypertrophy by promoting telomere\/telomerase function, which may be associated with the activation of the ERK1\/2\u2010Nrf2 signaling pathway in vitro.<\/jats:p>","DOI":"10.1002\/cbin.11799","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T12:23:07Z","timestamp":1647865387000},"page":"1036-1046","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dexmedetomidine attenuates hypoxia\u2010induced cardiomyocyte injury by promoting telomere\/telomerase activity: Possible involvement of ERK1\/2\u2010Nrf2 signaling pathway"],"prefix":"10.1002","volume":"46","author":[{"given":"Wei","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Hunan Children's Hospital Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hunan Children's Hospital Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hunan Children's Hospital Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2017.12.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-019-0466-y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043456016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6136105"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6863"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1997.0503"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.10.e47"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-010-0703-3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2011.07.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8010019"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-016-0613-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/L19-0603"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.65.092101.142243"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.155"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03325250"},{"issue":"11","key":"e_1_2_8_17_1","article-title":"The effects of resveratrol on telomeres and post myocardial infarction remodeling","volume":"12","author":"Gutlapalli S. 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