{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:22:19Z","timestamp":1768443739694,"version":"3.49.0"},"reference-count":88,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:00:00Z","timestamp":1653091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302938\/2020\u20106"],"award-info":[{"award-number":["302938\/2020\u20106"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prostate is not an organ exclusive to the male. It is also found in females of several species, including humans, in which part of the Skene gland is homologous to the male prostate. Evidence is accumulating that changes in the stroma are central to tumorigenesis. Equally, telocytes, a recently discovered type of interstitial cell, are essential for the maintenance of stromal organization. However, it is still uncertain whether there are telocytes in the female prostate and if they play a role in tumorigenesis. The present study used ultrastructural and immunofluorescence techniques to investigate the presence of telocytes in the prostate of Mongolian gerbil females, a rodent model that often has a functional prostate in females, as well as to assess the impact of a combination of <jats:italic>N<\/jats:italic>\u2010ethyl\u2010<jats:italic>N<\/jats:italic>\u2010nitrosourea, testosterone, and estradiol on telocytes. The results point to the presence of telocytes in the female prostate in the perialveolar and interalveolar regions, and reveal that these cells are absent in regions of benign and premalignant lesions in the gland, in which the perialveolar smooth muscle is altered. Additionally, telocytes are also closely associated with infiltrated immune cells in the stroma. Our data suggest that telocytes are important for both the maintenance of smooth muscle and prostatic epithelium integrity, which indicates a protective role against the advancement of tumorigenesis. But telocytes are also associated with immune cells and a proinflammatory\/proangiogenic role for these cells cannot be ruled out, implying that telocytes have a complex role in prostatic tumorigenesis in females.<\/jats:p>","DOI":"10.1002\/cbin.11816","type":"journal-article","created":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T06:24:30Z","timestamp":1653200670000},"page":"1495-1509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The complex role of telocytes in female prostate tumorigenesis in a rodent model"],"prefix":"10.1002","volume":"46","author":[{"given":"Juliana S.","family":"Maldarine","sequence":"first","affiliation":[{"name":"Department of Structural and Functional Biology, Institute of Biology State University of Campinas (UNICAMP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno D. A.","family":"Sanches","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology, Institute of Biology State University of Campinas (UNICAMP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vit\u00f3ria A.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Laboratory of Microscopy and Microanalysis Universidade Estadual Paulista\u2014UNESP S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rejane M.","family":"G\u00f3es","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Laboratory of Microscopy and Microanalysis Universidade Estadual Paulista\u2014UNESP S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia S. L.","family":"Vilamaior","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Laboratory of Microscopy and Microanalysis Universidade Estadual Paulista\u2014UNESP S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3080-9447","authenticated-orcid":false,"given":"Hernandes F.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology, Institute of Biology State University of Campinas (UNICAMP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebasti\u00e3o R.","family":"Taboga","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology, Institute of Biology State University of Campinas (UNICAMP) S\u00e3o Paulo Brazil"},{"name":"Department of Biological Sciences, Laboratory of Microscopy and Microanalysis Universidade Estadual Paulista\u2014UNESP S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,21]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"106","article-title":"Female paraurethral prostate gland in bitches","volume":"6","author":"Aguiar A. C. S.","year":"2013","journal-title":"Brazilian Journal of Veterinary Pathology"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12624"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.652747"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01119.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488807781696249"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10759"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-287"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12071887"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/iep.12120"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12711"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-011-9340-x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12529"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20187544"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.69.3.426-439.2005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12021"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.5935\/1676-2444.20160041"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17081322"},{"key":"e_1_2_9_19_1","first-page":"81","article-title":"Androgenic effects upon prostatic epithelium are mediated via trophic influences from stroma","volume":"145","author":"Cunha G. R.","year":"1984","journal-title":"Progress in Clinical and Biological Research"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2018.08.005"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2009.00685.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.10.64"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-0267-9"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2090"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888x10666151001115111"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02408.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40465-1"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-5538.IBJU.2016.0484"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12436"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0940-9602(02)80051-6"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/iep.12050"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23181"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-012-1333-8"},{"key":"e_1_2_9_34_1","first-page":"435","article-title":"Female urethral syndrome. A female prostatitis?","volume":"164","author":"Gittes R. F.","year":"1996","journal-title":"Western Journal of Medicine"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22669"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2009.09.017"},{"key":"e_1_2_9_37_1","first-page":"77","article-title":"Comparative morphology of the prostate in adult male and female Praomys (Mastomys) natalensis studied with electron microscopy","volume":"19","author":"Gross S. A.","year":"1987","journal-title":"Journal of Submicroscopic Cytology"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.668349"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-1061-3_4"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1457-z"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01002772"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65299-0"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-11-0726"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2016.02.023"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0509-3"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008588"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689719842514"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888x10666150630112035"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102158"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD19106"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01449.x"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2019.151442"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33126-2"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0012-1606(02)00031-3"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.27340"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23045"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12571"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00086"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/iep.12153"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2010.00756.x"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.5603\/FM.a2015.0123"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pgp.0000101144.79462.39"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01059.x"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2009.03.019"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.125906"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.02.021"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-1061-3_13"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11214"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11458"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24196"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23364"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13234"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2017.07.013"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11612"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78532-7"},{"key":"e_1_2_9_76_1","first-page":"3","article-title":"Female prostate: A review about the biological repercussions of this gland in humans and rodents","volume":"3","author":"Santos F. C. A.","year":"2006","journal-title":"Animal Reproduction"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.04033.x"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1661"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-2-2"},{"key":"e_1_2_9_80_1","first-page":"161","article-title":"Characterization of N\u2010ethyl\u2010N\u2010nitrosourea\u2014induced mammary tumors in the rat","volume":"110","author":"Stoica G.","year":"1983","journal-title":"American Journal of Pathology"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-017-0322-9"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65620-0"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00460-4"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02217-y"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1159\/000474724"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12195"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-1061-3_18"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/pl00022920"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-10-188"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11816","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbin.11816","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T21:46:45Z","timestamp":1692827205000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.11816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,21]]},"references-count":88,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/cbin.11816"],"URL":"https:\/\/doi.org\/10.1002\/cbin.11816","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,21]]},"assertion":[{"value":"2021-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}