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Clinically, these diseases appear to be unrelated, but pathogenic pathways have been shown to connect them. While inflammation is a common occurrence in the body, it may either stimulate a favorable immune response to protect against harmful signals or cause illness by damaging cells and tissues. Nanomedicine has tremendous promise for regulating inflammation and treating IMIDs. Various nanoparticles coated with nanotherapeutics have been recently fabricated for effective targeted delivery to inflammatory tissues. RNA interference (RNAi) offers a tremendous genetic approach, particularly if traditional treatments are ineffective against IMDs. In cells, several signaling pathways can be suppressed by using RNAi, which blocks the expression of particular messenger RNAs. Using this molecular approach, the undesirable effects of anti\u2010inflammatory medications can be reduced. Still, there are many problems with using short\u2010interfering RNAs (siRNAs) to treat IMDs, including poor localization of the siRNAs in target tissues, unstable gene expression, and quick removal from the blood. Nanotherapeutics have been widely used in designing siRNA\u2010based carriers because of the restricted therapy options for IMIDs. In this review, we have discussed recent trends in the fabrication of siRNA nanodelivery systems, including lipid\u2010based siRNA nanocarriers, liposomes, and cationic lipids, stable nucleic acid\u2010lipid particles, polymeric\u2010based siRNA nanocarriers, polyethylenimine (PEI)\u2010based nanosystems, chitosan\u2010based nanoformulations, inorganic material\u2010based siRNA nanocarriers, and hybrid\u2010based delivery systems. We have also introduced novel siRNA\u2010based nanocarriers to control IMIDs, such as pulmonary inflammation, psoriasis, inflammatory bowel disease, ulcerative colitis, rheumatoid arthritis, etc. This study will pave the way for new avenues of research into the diagnosis and treatment of IMDs.<\/jats:p>","DOI":"10.1002\/cbin.11841","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T16:34:20Z","timestamp":1657730060000},"page":"1320-1344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["siRNA\u2010based nanotherapeutics as emerging modalities for immune\u2010mediated diseases: A preliminary review"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2255-5977","authenticated-orcid":false,"given":"Saman","family":"Sargazi","sequence":"first","affiliation":[{"name":"Cellular and Molecular Research Center Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences Zahedan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Quaid\u2010i\u2010Azam University Islamabad Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Ghamari","sequence":"additional","affiliation":[{"name":"Department of Biotechnology National Institute of Genetic Engineering and Biotechnology Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Rahdar","sequence":"additional","affiliation":[{"name":"Department of Physics University of Zabol Zabol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9825-0806","authenticated-orcid":false,"given":"Ali","family":"Bakhshi","sequence":"additional","affiliation":[{"name":"School of Physics Institute for Research in Fundamental Sciences (IPM) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Fathi","family":"Karkan","sequence":"additional","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Department of Medical Nanotechnology Faculty of Advanced Medical Sciences Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Ajalli","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering University of Tehran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Bilal","sequence":"additional","affiliation":[{"name":"School of Life Science and Food Engineering Huaiyin Institute of Technology Huaian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7405-2354","authenticated-orcid":false,"given":"Ana M.","family":"D\u00edez\u2010Pascual","sequence":"additional","affiliation":[{"name":"Universidad de Alcal\u00e1, Facultad de Ciencias, Departamento de Quimica Anal\u00edtica Qu\u00edmica F\u00edsica e Ingenier\u00eda Qu\u00edmica, Ctra. 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