{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T07:14:48Z","timestamp":1763968488852,"version":"3.37.3"},"reference-count":127,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Macrophages, the most heterogeneous cells of the hematopoietic system and the giant eaters of the immune system that present either as tissue\u2010resident cells or infiltrated immune cells, eliminate foreign pathogens and microbes and also play different physiological roles to maintain the body's immune response. In this review, we basically provide a broad overview of macrophages from their origin, functional diversity to M1\u2010M2 polarization, specialized markers, and their role as important therapeutic targets in different diseases based on the current research and evidence. Apart from this, we have precisely discussed about tumor\u2010associated macrophages (TAMs) and their role in tumor progression and newly discovered lesser\u2010known markers of TAMs that could be used as potential therapeutic targets to treat life\u2010threatening diseases. It is really very important to understand the diversity of macrophages to develop TAM\u2010modulating strategies to activate our own immune system against diseases and to overcome immune resistance.<\/jats:p>","DOI":"10.1002\/cbin.11914","type":"journal-article","created":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T18:19:05Z","timestamp":1664734745000},"page":"15-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Origin, production\u00a0and molecular determinants of macrophages for their therapeutic targeting"],"prefix":"10.1002","volume":"47","author":[{"given":"Sangita","family":"Chowdhury","sequence":"first","affiliation":[{"name":"LSS008 Division of Cancer Biology CSIR\u2010Central Drug Research Institute Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6316-0947","authenticated-orcid":false,"given":"Arun K.","family":"Trivedi","sequence":"additional","affiliation":[{"name":"LSS008 Division of Cancer Biology CSIR\u2010Central Drug Research Institute Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29519"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-017-0004-z"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-015-0874-1"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.11.013"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8291-9"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0232-1"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00480"},{"key":"e_1_2_12_9_1","first-page":"521","article-title":"The pulmonary interstitial cell as immediate precursor of the alveolar macrophage","volume":"68","author":"Bowden D. H.","year":"1972","journal-title":"The American Journal of Pathology"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.67.1.97"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1100\/2011\/213962"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.169"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00263"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22076"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2008.00004.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0568-z"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2015.02.02"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0195"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0012"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13490"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100587"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2705"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2017.04.007"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0615-z"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c120026"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2010.03.003"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(88)90069-7"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.013"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.03.151"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/815953"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4834"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-013-9621-3"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-1885"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.128.3.415"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00420"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.04.084"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20182361"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901368"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.02.016"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.026"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.05.007"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22396"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337007"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24556"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.139887"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807233390404"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.03.011"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-379214"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145342"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2018.12.016"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710754114"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402797"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-341123"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.00865.x"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.uct.2007.06.001"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-073841"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0462-y"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082173"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.125211"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9089610"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.113371dl"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12439"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR00523A"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-020-01342-3"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45444"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers3043740"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.06.008"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0760-3"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00034"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-6470-2"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3737"},{"volume-title":"Brenner's encyclopedia of genetics","year":"2013","author":"Maloy S.","key":"e_1_2_12_72_1"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.217"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(07)00002-6"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.2741\/2692"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.12703\/P6-13"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.2741\/2692"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-20-0268"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2014.05.005"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01276"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034339"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1022-2"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.12.057"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.010"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01084"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.11.2346"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.08.128"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23238"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2528"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10138"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjv042"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.301174"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3265"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.010"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02628"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-54090-0_3"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908641106"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13002"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-017-0480-8"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5160794"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1242974"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2735"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.07.012"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021857"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(99)00030-0"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11091400"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8459193"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2016.05.009"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060834"},{"key":"e_1_2_12_110_1","first-page":"425","article-title":"Macrophage infiltration and its prognostic implications in breast cancer: The relationship with VEGF expression and microvessel density","volume":"14","author":"Tsutsui S.","year":"2005","journal-title":"Oncology Reports"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301453"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80006"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2064"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2016.09.001"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3RU1018-378RR"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00614"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgq088"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2019.1683347"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-017-1953-7"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2013-1293"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00792"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27259"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173090"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.5681\/apb.2013.053"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000308"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153550"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202293"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200662"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbin.11914","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T22:48:50Z","timestamp":1692571730000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.11914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,2]]},"references-count":127,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/cbin.11914"],"URL":"https:\/\/doi.org\/10.1002\/cbin.11914","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"type":"print","value":"1065-6995"},{"type":"electronic","value":"1095-8355"}],"subject":[],"published":{"date-parts":[[2022,10,2]]},"assertion":[{"value":"2022-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}