{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T11:14:31Z","timestamp":1759058071335,"version":"3.37.3"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The orthopoxvirus (OPV) genus includes several species that infect humans, including variola, monkeypox, vaccinia, and cowpox. Variola and monkeypox are often life\u2010threatening diseases, while vaccinia and cowpox are usually associated with local lesions. The epidemic potential for OPVs may be lower than respiratory\u2010borne viruses or RNA viruses. However, OPVs are notable for their spread and distribution in different environments and among different hosts. The emergence or re\u2010emergence of OPVs in the human population can also occur in wild or domestic animals as intermediate hosts. More effective and safer vaccines for poxvirus can be developed by understanding how immunity is regulated in poxvirus and vaccines for DNA viruses. Downstream events in cells affected by the virus are regulated functionally by a series of characteristics that are affected by host cell interactions and responses of cells against viral infections, including the interferon pathway and apoptosis. Furthermore, infection outcome is greatly influenced by the distinct selection of host\u2010range and immune\u2010modulatory genes that confer the potential for pathogenesis and host\u2010to\u2010host transmission and the distinct host\u2010range properties of each immune\u2010modulatory gene. The present study reviewed the effective factors in human\u2010restricted tropism and virus pathogenicity in OPVs.<\/jats:p>","DOI":"10.1002\/cbin.11941","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T08:06:25Z","timestamp":1667289985000},"page":"341-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effective factors in human\u2010specific tropism and viral pathogenicity in orthopoxviruses"],"prefix":"10.1002","volume":"47","author":[{"given":"Soad","family":"Ghabeshi","sequence":"first","affiliation":[{"name":"Virology Department, School of Public Health Tehran University of Medical Sciences Tehran Iran"},{"name":"Health Policy Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9986-4930","authenticated-orcid":false,"given":"Sorayya","family":"Ghasemi","sequence":"additional","affiliation":[{"name":"Cancer Research Center Shahrekord University of Medical Sciences Shahrekord Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2507-2145","authenticated-orcid":false,"given":"Leila","family":"Mousavizadeh","sequence":"additional","affiliation":[{"name":"Department of Virology, School of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00304-15"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2012.12.002"},{"key":"e_1_2_12_4_1","unstructured":"Chahroudi A.(2006).Orthopoxvirus tropism and immunogenicity: Emory University."},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.69.10.6605-6608"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01835-08"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.3.022502.103149"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/505224"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.262668999"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007666"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1125134"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-6445(00)00027-9"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2006.09.006"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13040575"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty407"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2013.10.014"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02015-14"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/v2091933"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.11.7550"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2005.07.015"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.567348"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-012-1174-2"},{"volume-title":"Lippincott Williams & Wilkinson","year":"2013","author":"Knipe D. M.","key":"e_1_2_12_23_1"},{"issue":"5","key":"e_1_2_12_24_1","first-page":"593","article-title":"A human infection caused by monkeypox virus in basankusu territory, democratic republic of the Congo","volume":"46","author":"Ladnyj I. D.","year":"1972","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.03.012"},{"key":"e_1_2_12_26_1","first-page":"26","article-title":"Smallpox and global governance","volume":"2012","author":"Leon D.","year":"2012","journal-title":"Global Governance Audit"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81215-0"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2013.825447"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2018.06.024"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1099"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01833-15"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01260-09"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06140-11"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006884"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.6371"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-9525(01)02447-7"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.2.1303"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.19.9683"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/738020"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05505-11"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omto.2019.05.003"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2009.05.006"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/v9110340"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/v9090242"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-014-1449-x"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00004-08"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.8.5504"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2009.0073"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(90)90296-4"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr859"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2012.06.005"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/524743"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.16461"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13010043"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2009.01.007"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7643-7557-7_1"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.05.077"},{"key":"e_1_2_12_58_1","unstructured":"World health Organization. (2022 May 21). Disease Outbreak News; Multi\u2010country monkeypox outbreak in non\u2010endemic countries.https:\/\/wwwwhoint\/emergencies\/disease-outbreak-news\/item\/2022-DON385"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2022.105220"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11941","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbin.11941","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T23:04:31Z","timestamp":1692486271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.11941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/cbin.11941"],"URL":"https:\/\/doi.org\/10.1002\/cbin.11941","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"type":"print","value":"1065-6995"},{"type":"electronic","value":"1095-8355"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"2022-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}