{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:58Z","timestamp":1786977358464,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary sclerosing cholangitis (PSC) is a progressive liver disease for which there is no effective therapy. Hepatocytes and cholangiocytes from a PSC patient were cocultured with mesenchymal stem cells (MSCs) to assess in vitro change. A single patient with progressive PSC was treated with 150 million MSCs via direct injection into the common bile duct. Coculture of MSCs with cholangiocytes and hepatocytes showed in vitro improvement. Local delivery of MSCs into a single patient with progressive PSC was safe. Radiographic and endoscopic evaluation showed stable distribution of multifocal structuring in the early postoperative period. MSCs may be effective for the treatment of PSC.<\/jats:p>","DOI":"10.1002\/cbin.11943","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T06:33:50Z","timestamp":1667370830000},"page":"467-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mesenchymal stem cells: A novel treatment option for primary sclerosing cholangitis"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3220-7148","authenticated-orcid":false,"given":"Amy L.","family":"Lightner","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Digestive Disease and Surgery Institute, Cleveland Clinic Cleveland Ohio USA"},{"name":"Department of Inflammation and Immunity Lerner Research Institute, Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Dadgar","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Digestive Disease and Surgery Institute, Cleveland Clinic Cleveland Ohio USA"},{"name":"Department of Inflammation and Immunity Lerner Research Institute, Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Department of Abdominal Transplantation Digestive Disease and Surgery Institute, Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of General Surgery Digestive Disease and Surgery Institute, Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifton","family":"Fulmer","sequence":"additional","affiliation":[{"name":"Department of Pathology Digestive Disease and Surgery Institute, Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Siddiki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Digestive Disease and Surgery Institute, Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. V.","family":"Narayanan Menon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Digestive Disease and Surgery Institute, Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology Imaging Institute, Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Matthew Walsh","sequence":"additional","affiliation":[{"name":"Department of General Surgery Digestive Disease and Surgery Institute, Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"MET and epidermal growth factor signaling: The pillars of liver regeneration?","author":"Albrecht J. H.","year":"2016"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228874"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-56"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X656045"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2014-0199"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00094.2020"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.214841"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41378-020-00201-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6542a3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0979-x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2015.08.014"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-003-0490-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0052-6"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181973487"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2015.01.002"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.04.117"},{"key":"e_1_2_9_19_1","first-page":"11","article-title":"Cholangiocyte proliferation and liver fibrosis","volume":"2","author":"Glaser S. S.","year":"2009","journal-title":"Expert Reviews in Molecular Medicine"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.01.015"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21371"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2014.49"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2013.0554"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA04954A"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1506330"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1357"},{"issue":"4","key":"e_1_2_9_27_1","first-page":"3983","article-title":"Antifibrotic potential of bone marrowderived mesenchymal stem cells in biliary atresia mice","volume":"18","author":"Lei J.","year":"2018","journal-title":"Molecular Medicine Reports"},{"issue":"1","key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1365-2184.2008.00491.x","article-title":"Long\u2010term clinical results of autologous infusion of mobilized adult bone marrow derived CD34+ cells in patients with chronic liver disease: CD34+ cells in chronic liver disease","volume":"41","author":"Levi\u010dar N.","year":"2008","journal-title":"Cell Proliferation"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000077"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.06.014"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.02.056"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31203-X"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21488"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-012-1581-9"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000152"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.061"},{"issue":"7","key":"e_1_2_9_37_1","first-page":"2102","article-title":"Effects of human amnion\u2010derived mesenchymal stem cells and conditioned medium in rats with sclerosing cholangitis","volume":"10","author":"Sugiura R.","year":"2018","journal-title":"American Journal of Translational Research"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11943","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbin.11943","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T18:08:38Z","timestamp":1701281318000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.11943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/cbin.11943"],"URL":"https:\/\/doi.org\/10.1002\/cbin.11943","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,2]]},"assertion":[{"value":"2022-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}