{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T10:55:18Z","timestamp":1769079318341,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a few reports, <jats:italic>ARID1B\/A<\/jats:italic> mutation was found in neuroblastoma. We analyzed the clinical characteristics, clinical efficacy, and prognosis of three children with high\u2010risk refractory neuroblastoma (NB) with somatic <jats:italic>ARID1B<\/jats:italic> gene mutation. The whole exon sequencing results showed that there were involved in transcription, DNA synthesis, and repair of <jats:italic>ARID1B<\/jats:italic> gene mutations. All mutation sites were located in the promoter region of the exon: <jats:italic>ARID1B<\/jats:italic> (p.A460) mutation was found in cases 1 and 2, and <jats:italic>ARID1B<\/jats:italic> (p.V215G) mutation was found in cases 1 and 3. The nucleic acid site of <jats:italic>ARID1B<\/jats:italic> (p.A460) mutation was c.1379 (exon1) C\u2009&gt;\u2009G, and the nucleic acid site of <jats:italic>ARID1B<\/jats:italic> (p.V215G) mutation was c.644 (exon1) T\u2009&gt;\u2009G. The meningeal metastasis in case 1 turned negative after 4 cycles of intrathecal injection combined with chemotherapy. However, the child died of agranulocytosis combined with sepsis during the 5th cycle of chemotherapy. Case 2 achieved complete remission (CR). Case 3 achieved CR after chemotherapy, surgery, metaiodobenzylguanidine, and 3F\u20108 (Naxitamab) immunotherapy after the initial diagnosis. The mediastinum and lymph node metastasis occurred during the 6\u2010month observation period after stopping treatment. He achieved very good partial remission after individualized chemotherapy and surgical treatment. <jats:italic>ARID1B<\/jats:italic> is a component protein of the SWI\/SNF chromatin\u2010remodeling complex that participates in the occurrence of a variety of tumors by regulating DNA repair and synthesis. <jats:italic>ARID1B<\/jats:italic> nucleic acid mutation (p.A460, p.V215G) in the promoter region of three children may contribute to the poor prognosis of NB children.<\/jats:p>","DOI":"10.1002\/cbin.12013","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T14:40:00Z","timestamp":1678286400000},"page":"1222-1228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Correlation between ARID1B gene mutation (p.A460, p.V215G) and prognosis of high\u2010risk refractory neuroblastoma"],"prefix":"10.1002","volume":"47","author":[{"given":"Yi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9333-5568","authenticated-orcid":false,"given":"Dongsheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huali","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Beijing Tongren Hospital Capital Medical University  Beijing 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