{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:29:51Z","timestamp":1792625391017,"version":"4.5.0"},"reference-count":77,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22076104"],"award-info":[{"award-number":["22076104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92043301"],"award-info":[{"award-number":["92043301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many indicators, including red cell distribution width (RDW) and iron metabolism, are sensitive to a variety of risk factors, and are associated with the pathological alterations and disease onset. RDW reflects the degree of heterogeneous volumes of peripheral red blood cells (RBCs). It has been well\u2010known that increased RDW indicates iron deficiency anemia, hemolytic anemia, ineffective erythropoiesis, and shorten lifespan of RBCs. Increased RDW is also prevalent in various non\u2010anemic pathological conditions and diseases. We here review the factors affecting RDW, particularly disordered iron metabolism, chronic inflammation, and oxidative stress, and recapitulate the interplays among these factors. Furthermore, we review the application of increased RDW together with disordered iron homeostasis and the deregulations of hepcidin expression and ferritin levels in the diagnoses and prognosis of anemic and nonanemic diseases. RDW is inexpensive and readily available and may be valuable in adding to the diagnosis and monitoring of many pathological conditions. RDW combined with other indicators, for example, hepcidin and ferritin levels, should be utilized more frequently in clinical practice.<\/jats:p>","DOI":"10.1002\/cbin.12029","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T10:32:13Z","timestamp":1682332333000},"page":"1161-1169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Promising applications of red cell distribution width in diagnosis and prognosis of diseases with or without disordered iron metabolism"],"prefix":"10.1002","volume":"47","author":[{"given":"Yashuang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong China"},{"name":"Shandong Key Laboratory of Endocrinology and Lipid Metabolism Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanshu","family":"Wang","sequence":"additional","affiliation":[{"name":"Biomedical Sciences College &amp; Shandong Medicinal Biotechnology Centre, Shandong First Medical University Jinan Shandong China"},{"name":"Medical Science and Technology Innovation Center, Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong China"},{"name":"Shandong Key Laboratory of Endocrinology and Lipid Metabolism Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijin","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical Science and Technology Innovation Center, Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong China"},{"name":"Shandong Key Laboratory of Endocrinology and Lipid Metabolism Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Centre for Respiratory Diseases, National Center for Respiratory Medicine, China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1586-0559","authenticated-orcid":false,"given":"Shuping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biomedical Sciences College &amp; Shandong Medicinal Biotechnology Centre, Shandong First Medical University Jinan Shandong China"},{"name":"Medical Science and Technology Innovation Center, Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-1-26"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319870344"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-015-0337-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.67.suppl1.20200678"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2013.07.002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12050816"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2021.04.011"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/dx-2015-0010"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3041565"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1401038"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-05-815944"},{"issue":"4","key":"e_1_2_10_13_1","first-page":"11","article-title":"Relationship between red cell distribution width and clinical outcome in patients with acute coronary syndrome","volume":"70","author":"Chandregowda Y. S.","year":"2022","journal-title":"Journal of the Association of Physicians of India"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14092"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R117.781823"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.09.006"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018018465"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2011.04.009"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.09.58"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1804281"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58050613"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-019-0637-4"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3871-7"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-010-0510-x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-020-00657-w"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.1203a151"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.364208"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-019-0542-7"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570161120666220527093551"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0066-7"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.18087\/cardio.2022.4.n1813"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-021-00742-7"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.21.078"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa217"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.09.001"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31825e2a85"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113732"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23850"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2022.107178"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105436"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24423"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00084"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.10.50"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-22-119"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2022.154069"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.20210997"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1569"},{"issue":"2","key":"e_1_2_10_48_1","first-page":"217","article-title":"High serum ferritin is associated with worse outcome of patients with decompensated cirrhosis","volume":"30","author":"Oikonomou T.","year":"2017","journal-title":"Annals of Gastroenterology"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euros.2022.01.003"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2012.10.002"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glp163"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5184354"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2014.992064"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-022-06608-y"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-022-02721-2"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7092151"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342229"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000612"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2021-1398"},{"issue":"4","key":"e_1_2_10_60_1","first-page":"S89","article-title":"Nutritional and immunological parameters as prognostic factors in patients with advanced oral cancer","volume":"88","author":"Trevisani L. F. M.","year":"2021","journal-title":"Brazilian Journal of Otorhinolaryngology"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00554.2011"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002296"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2022.2079668"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2021.106844"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwaa226"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-017-0919-x"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104664"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11071951"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2022.2059558"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264504"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2020.04.008"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.01.396"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202000383"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04490-1"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-6348"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI120849"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom8030080"},{"issue":"10","key":"e_1_2_10_78_1","first-page":"1841","article-title":"Baseline red blood cell distribution width correlates with disease activity and therapeutic outcomes in patients with systemic lupus erythematosus, irrespective of anemia status","volume":"62","author":"Zou X. L.","year":"2016","journal-title":"Clinical Laboratory"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.12029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T09:17:29Z","timestamp":1692436649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.12029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,24]]},"references-count":77,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/cbin.12029"],"URL":"https:\/\/doi.org\/10.1002\/cbin.12029","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,24]]},"assertion":[{"value":"2022-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}