{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:02:36Z","timestamp":1790089356933,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:00:00Z","timestamp":1688688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neural precursor cell\u2010expressed developmentally downregulated gene 4 (NEDD4) is an E3 ubiquitin ligase that recognizes substrates via protein\u2013protein interactions and takes part in tumor development. This study aims to clarify NEDD4's functions in diffuse large B\u2010cell lymphoma (DLBCL) and its downstream mechanisms. Collection of 53 DLBCL tissues and adjacent normal lymphoid tissues, and detection of NEDD4 and Forkhead box protein A1 (FOXA1) in the tissues were conducted. The selection of DLBCL cells was for FARAGE, and test of cells' advancement was after transfection. Analysis of NEDD4 and FOXA1's link, and test of Wnt\/\u03b2\u2010catenin pathway were implemented. In vivo tumor xenograft experiments were put into effect. Detection of the pathological conditions of tumor tissues and the positive Ki67 in the family was implemented. It came out NEDD4 was reduced in DLBCL tissues and cell lines, and FOXA1 was elevated; Enhancing NEDD4 or repressing FOXA1 refrained DLBCL cells' advancement; NEDD4 could combine with FOXA1 and trigger its ubiquitination and degradation; NEDD4 inactivates the Wnt\/\u03b2\u2010catenin pathway by motivating FOXA1 ubiquitination; NEDD4 enhancement refrained DLBCL growth in vivo. In conclusion, the E3 ubiquitin ligase NEDD4 accelerates FOXA1 ubiquitination but refrains DLBCL cell proliferation via the Wnt\/\u03b2\u2010Catenin pathway.<\/jats:p>","DOI":"10.1002\/cbin.12061","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T07:11:25Z","timestamp":1688713885000},"page":"1688-1701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["E3 ubiquitin ligase neural precursor cell\u2010expressed developmentally downregulated gene 4 motivates FOXA1 ubiquitination and restrains proliferation of diffuse large B\u2010cell lymphoma cells via the Wnt\/\u03b2\u2010Catenin pathway"],"prefix":"10.1002","volume":"47","author":[{"given":"Li","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Chongqing Medical University Chongqing City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7483-1603","authenticated-orcid":false,"given":"Jun Nan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Chongqing Medical University Chongqing City China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-019-04784-w"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2014.12.020"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0474-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.571914"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S249429"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199398"},{"issue":"6","key":"e_1_2_9_8_1","first-page":"1433","article-title":"High expression and nuclear localization of \u03b2\u2010catenin in diffuse large B\u2010cell lymphoma","volume":"5","author":"Ge X.","year":"2012","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S212317"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI147025"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102122"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgab013"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6532"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8020165"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0258315","article-title":"Predicting PY motif\u2010mediated protein\u2010protein interactions in the Nedd4 family of ubiquitin ligases","volume":"16","author":"Katherine H. A.","year":"2021","journal-title":"PLoS One"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.09.017"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-020-06068-5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8935-5_26"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-021-00651-8"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1896-7_15"},{"issue":"4","key":"e_1_2_9_21_1","first-page":"1041","article-title":"FOXA1 promotes proliferation, migration and invasion by transcriptional activating KRT7 in human gastric cancer cells","volume":"33","author":"Liu B. L.","year":"2019","journal-title":"Journal of Biological Regulators and Homeostatic Agents"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25460"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2020.104451"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2021.1941608"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3598"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.197"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-021-03730-3"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-019-0190-9"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9995869"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.111958"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215557"},{"issue":"11","key":"e_1_2_9_32_1","first-page":"7340","article-title":"FBN1 promotes DLBCL cell migration by activating the Wnt\/\u03b2\u2010catenin signaling pathway and regulating TIMP1","volume":"12","author":"Wang H.","year":"2020","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-020-00321-1"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.08.151"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2018.03.002"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202247"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2019.12.009"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.03.006"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2021.108998"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.03.006"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12247"},{"issue":"4","key":"e_1_2_9_42_1","first-page":"341","article-title":"Medical statistics as a foundation of biomedical research","volume":"74","author":"Yoshitaka M.","year":"2022","journal-title":"Brain and Nerve"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2021.1885232"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S299715"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24036"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202185"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S314709"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.12061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T09:22:29Z","timestamp":1694510549000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.12061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,7]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/cbin.12061"],"URL":"https:\/\/doi.org\/10.1002\/cbin.12061","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,7]]},"assertion":[{"value":"2022-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}