{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:47:25Z","timestamp":1768448845942,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several studies have revealed that vitamin D deficiency is linked to an increased risk of developing coronavirus disease 19 (COVID\u201019). In individuals with the severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infections, vitamin D receptor activation is required to decrease acute respiratory distress syndrome. The purpose of this study was to examine the genotypic distribution and allelic frequencies of CDX2 rs11568820 and <jats:italic>EcoRV<\/jats:italic> rs4516035 polymorphisms in COVID\u201019 patients with various SARS\u2010CoV\u20102 variants. For genotyping of CDX2 rs11568820 and <jats:italic>EcoRV<\/jats:italic> rs4516035 polymorphisms, we used the polymerase chain reaction\u2010restriction fragment length polymorphism technique in 1734 and 1450 recovered and deceased patients, respectively. The results indicated the rate of COVID\u201019 mortality was associated with CDX2 rs11568820 AA and GA genotypes in the Delta variant and with CDX2 rs11568820 AA in the Omicron BA.5 variant, while no association was shown in the Alpha variant. Therefore, the rate of COVID\u201019 mortality was associated with <jats:italic>EcoRV<\/jats:italic> rs4516035 TC and CC genotypes in the Delta variant, while no association was shown in the Alpha and Omicron BA.5 variants. According to our analysis, the T\u2010G haplotype was more common in all SARS\u2010CoV\u20102 variants. The C\u2010A haplotype was associated with COVID\u201019 mortality in the Delta and Omicron BA.5 variants, and the T\u2010A haplotype was related to the Alpha variant. In conclusion, the genotype frequencies of the CDX2 rs11568820 and <jats:italic>EcoRV<\/jats:italic> rs4516035 polymorphisms between SARS\u2010CoV\u20102 variants were significantly different between the deceased patients and recovered patients. However, more studies should be done to confirm the results.<\/jats:p>","DOI":"10.1002\/cbin.12064","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T03:06:06Z","timestamp":1687921566000},"page":"1728-1736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Relationship between CDX2 rs11568820 and <i>EcoRV<\/i> rs4516035 polymorphisms on the vitamin D receptor gene with susceptibility to different SARS\u2010CoV\u20102 variants"],"prefix":"10.1002","volume":"47","author":[{"given":"Abed K. K.","family":"Al\u2010Mohammedawi","sequence":"first","affiliation":[{"name":"Department of Biology, Science and Research Branch Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enayat","family":"Anvari","sequence":"additional","affiliation":[{"name":"Clinical Research Development Unit, Shahid Mostafa Khomeini Hospital Ilam University of Medical Science Ilam Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2043-8523","authenticated-orcid":false,"given":"Abolfazl","family":"Fateh","sequence":"additional","affiliation":[{"name":"Department of Mycobacteriology and Pulmonary Research Pasteur Institute of Iran Tehran Iran"},{"name":"Microbiology Research Center (MRC) Pasteur Institute of Iran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2021.105098"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155957"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes13122346"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27588"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-018-4191-y"},{"key":"e_1_2_11_7_1","first-page":"1187","article-title":"Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine","volume":"89","author":"Borgna\u2010Pignatti C.","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.9.1632"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-021-00871-7"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-022-00434-8"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0695-z"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12040988"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602006"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa733"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01570-8"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12598"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123799"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-018-1063-5"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5988976"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/bjbs.2021.10237"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-009-0763-1"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-021-01614-4"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-022-00394-z"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-021-01692-z"},{"key":"e_1_2_11_25_1","volume-title":"Covid\u201019: Omicron may be more transmissible than other variants and partly resistant to existing vaccines, scientists fear","author":"Torjesen I.","year":"2021"},{"key":"e_1_2_11_26_1","first-page":"2021","volume-title":"Living guidance for clinical management of COVID\u201019: Living guidance","author":"World Health Organization .","year":"2021"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.12064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T09:22:52Z","timestamp":1694510572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.12064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,27]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/cbin.12064"],"URL":"https:\/\/doi.org\/10.1002\/cbin.12064","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,27]]},"assertion":[{"value":"2023-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}