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However, the deficiency of the systematic and detailed comparison of the biological and transcriptomic characteristics of the aforementioned stem cells largely hinders their application in regenerative medicine. Herein, we collected supernumerary teeth for SCAP\u2010S and DPSC isolation and identification by utilizing multiple biological tests (e.g., growth curve, cell cycle and apoptosis, adipogenic and osteogenic differentiation, and quantitative real\u2010time polymerase chain reaction). Furthermore, we took advantage of transcriptome sequencing and multifaceted bioinformatic analyses to dissect the similarities and diversities between them. In this study, we found that SCAP\u2010Ss and DPSCs showed indistinctive signatures in morphology and immunophenotypes, whereas with diversity in cell vitality and multi\u2010lineage differentiation as well as gene expression profiling and differentially expressed genes\u2010associated gene ontology and signaling pathways. Collectively, our data indicated the diversity of the multifaceted signatures of human supernumerary teeth\u2010derived stem cells both at the cellular and molecular levels, which also supplied new references for SCAP\u2010Ss serving as splendid alternative stem cell sources for regenerative medicine purposes.<\/jats:p>","DOI":"10.1002\/cbin.12088","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T05:25:16Z","timestamp":1693286716000},"page":"1976-1986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Decoding the multifaceted signatures and transcriptomic characteristics of stem cells derived from apical papilla and dental pulp of human supernumerary teeth"],"prefix":"10.1002","volume":"47","author":[{"given":"Juan","family":"Ning","sequence":"first","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6540-0943","authenticated-orcid":false,"given":"Leisheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor &amp; Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial Hospital Lanzhou China"},{"name":"Key Laboratory of Radiation Technology and Biophysics, Hefei Institute of Physical Science Chinese Academy of Sciences Hefei China"},{"name":"Jiangxi Health\u2010Biotech Stem Cell Technology Co., Ltd. Jiangxi Research Center of Stem Cell Engineering Shangrao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanjing","family":"Xie","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian","family":"Chai","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yao","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"1","article-title":"Visualized analyses of investigations upon mesenchymal stem\/stromal cell\u2010based cytotherapy and 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