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This significantly impacts the physical and mental health of women in their childbearing years. Telocytes (TCs), a distinctive type of interstitial cells found in various tissues and organs, play diverse repair functions due to their unique spatial structure. In this study, we conduct the inaugural exploration of the changes in TCs in IUA disease and their potential impact on the function of stem cells. Our results show that in vivo, through double immunofluorescence staining (CD34+\/Vimentin+; CD34+\/CD31\u2212),\u00a0as endometrial fibrosis deepens, the number of TCs gradually decreases, telopodes\u00a0shorten, and the three\u2010dimensional structure becomes disrupted in the mouse IUA mode. In vitro, TCs can promote the proliferation and cycle of bone mesenchymal stem cells (BMSCs) by promoting the Wnt\/\u03b2\u2010catenin signaling pathway, which were inhibited using XAV939. TCs can promote the migrated ability of BMSCs and contribute to the repair of stem cells during endometrial injury. In addition, TCs can inhibit the apoptosis of BMSCs through the Bcl\u20102\/Bax pathway. In conclusion, our study demonstrates, for the first time, the resistance role of TCs in IUA disease, shedding light on their potential involvement in endometrial repair through the modulation of stem cell function.<\/jats:p>","DOI":"10.1002\/cbin.12137","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T12:25:22Z","timestamp":1707913522000},"page":"647-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Histological study of telocytes in mice intrauterine adhesion model and their positive effect on mesenchymal stem cells in vitro"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0443-7296","authenticated-orcid":false,"given":"Xiaojiao","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Soochow University Suzhou City Jiangsu Province People's Republic 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