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Although osthole exhibits numerous pharmacological activities in treating various diseases, its therapeutic effect on PCOS is undiscovered. The present study found that application of osthole improved the symptoms of PCOS mice through preventing ovarian granulosa cells (GCs) production of more estrogen and alleviating the liberation of pro\u2010inflammatory cytokine\u00a0interleukin\u00a0(IL)\u20101\u03b2, IL\u20106, and\u00a0tumor necrosis factor alpha. Meanwhile, osthole enhanced ovarian antioxidant capacity and alleviated intracellular reactive oxygen species (ROS) accumulation with a concurrent attenuation for oxidative stress, while intervention of antioxidant enzymic activity and glutathione (GSH)\u00a0synthesis neutralized the salvation of osthole on GCs secretory disorder and chronic inflammation. Further analysis revealed that osthole restored the expression of nuclear factor erythroid 2\u2010related factor 2 (Nrf2)\u00a0and forkhead box O 1 (Foxo1) whose repression antagonized the amelioration of osthole on the insufficiency of antioxidant capacity and accumulation of ROS. Moreover, Nrf2 served as an intermedium to mediate the regulation of osthole on Foxo1. Additionally, osthole restricted the phosphorylation of I\u03baB\u03b1 and nuclear factor kappa B (NF\u2010\u03baB)\u00a0subunit p65 by DHEA and weakened the transcriptional activity of NF\u2010\u03baB, but this effectiveness was abrogated by the obstruction of Nrf2 and Foxo1, whereas adjunction of GSH renewed the redemptive effect of osthole on NF\u2010\u03baB whose activation caused an invalidation of osthole in rescuing the aberration of GCs secretory function and inflammation response. Collectively, osthole might relieve the symptoms of PCOS mice via Nrf2\u2010Foxo1\u2010GSH\u2010NF\u2010\u03baB pathway.<\/jats:p>","DOI":"10.1002\/cbin.12170","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T04:44:03Z","timestamp":1715661843000},"page":"1111-1123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Osthole exhibits the remedial potential for polycystic ovary syndrome mice through Nrf2\u2010Foxo1\u2010GSH\u2010NF\u2010\u03baB pathway"],"prefix":"10.1002","volume":"48","author":[{"given":"Shan","family":"Jin","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Jilin University Changchun P.R. China"},{"name":"Reproductive Medical Center, The Second Hospital of Jilin University Changchun P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Si","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Jilin University Changchun P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Cheng","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Jilin University Changchun P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Jilin University Changchun P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai\u2010Yu","family":"Li","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Jilin University Changchun P.R. 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