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Cytokines, as important regulators of cancer development, have great potential for the screening and prognosis of NSCLC. This study screened novel biomarkers related to the early screening and prognosis of NSCLC. In the present study, the biological significance and immunoregulation of interleukin\u201024\u00a0(IL\u201024) were analyzed based on The Cancer Genome Atlas data. Next, 150 serum samples from initially treated patients with NSCLC and 70 controls were collected, and we obtained pathological sections from 60 patients with NSCLC. The ELISA and immunohistochemistry\u00a0results showed the differential expression of IL\u201024 and carbohydrate antigen 125\u00a0(CA125). The results show that IL\u201024 is an important tumor suppressor in NSCLC\u00a0that helps to improve the poor prognosis of these patients. A significantly negative correlation between IL\u201024 and CA125 levels was also found. Notably, serum IL\u201024 levels were significantly negatively correlated with the TNM stage of patients with NSCLC, consistent with an important role for tumor suppressors in NSCLC. The receiver operating characteristic curve analysis showed that a combination of IL\u201024 and CA125 was an effective panel for discriminating patients with NSCLC from HD, and individuals with other lung diseases. Serum IL\u201024 and CA125 levels were identified as independent prognostic markers for NSCLC. The IL\u201024 and CA125 panel exhibited good performance in the screening of NSCLC.<\/jats:p>","DOI":"10.1002\/cbin.12173","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T04:50:21Z","timestamp":1715835021000},"page":"1160-1168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Serum IL\u201024 combined with CA125 as screening and prognostic biomarkers for NSCLC"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3730-5011","authenticated-orcid":false,"given":"Kai","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Third Affiliated Hospital of Zhengzhou University Zhengzhou Henan China"},{"name":"Zhengzhou Key Laboratory for In Vitro Diagnosis of Hypertensive Disorders of Pregnancy Zhengzhou Henan 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