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In this study, we demonstrated that GSE1 (genetic suppressor element 1) expression is aberrantly upregulated in lung adenocarcinoma and that GSE1 depletion inhibits the proliferation and migration of both A549 and H1299 cells. Immunoprecipitation assays demonstrated that GSE1 interacts with histone deacetylase 1 (HDAC1) and other BRAF\u2013HDAC complex (BHC) components in cells. The transcriptome of GSE1\u2010knockdown A549 cells indicated that 207 genes were upregulated and 159 were downregulated based on a <jats:italic>p<\/jats:italic>\u2010value\u2009&lt;\u2009.05 and fold change\u2009\u2265\u20091.5. Bioinformatics analysis suggested that 140 differentially expressed genes harbor binding sites for HDAC1, including the tumor suppressor gene <jats:italic>KLF6<\/jats:italic> (Kruppel\u2010like factor 6). Indeed, quantitative reverse\u2010transcription polymerase chain reaction and western blot analysis revealed that GSE1 could inhibit the transcription of <jats:italic>KLF6<\/jats:italic> in lung cancer cells. In conclusion, GSE1 cooperates with HDAC1 to promote the proliferation and metastasis of non\u2010small cell lung cancer cells through the downregulation of <jats:italic>KLF6<\/jats:italic> expression.<\/jats:p>","DOI":"10.1002\/cbin.12208","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T04:32:26Z","timestamp":1718685146000},"page":"1490-1506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["GSE1 promotes the proliferation and migration of lung adenocarcinoma cells by downregulating <i>KLF6<\/i> expression"],"prefix":"10.1002","volume":"48","author":[{"given":"Ziyu","family":"Meng","sequence":"first","affiliation":[{"name":"Department of General Surgery The First Affiliated Hospital of Anhui Medical University Hefei China"},{"name":"Department of General Surgery Anhui Public Health Clinical Center Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery The First Affiliated Hospital of Anhui Medical University Hefei China"},{"name":"Department of General Surgery Anhui Public Health Clinical Center Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shupei","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Science Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liguo","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Surgery The First Affiliated Hospital of Anhui Medical University Hefei China"},{"name":"Department of General Surgery Anhui Public Health Clinical Center Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhoujuan","family":"Yao","sequence":"additional","affiliation":[{"name":"College of Life Science Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery The First Affiliated Hospital of Anhui Medical University Hefei China"},{"name":"Department of General Surgery Anhui Public Health Clinical Center Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junkun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery The First Affiliated Hospital of Anhui Medical University Hefei China"},{"name":"Department of General Surgery Anhui Public Health Clinical Center Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiru","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Life Science Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Life Science Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0468-3526","authenticated-orcid":false,"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Science Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery The First Affiliated Hospital of Anhui Medical University Hefei China"},{"name":"Department of General Surgery Anhui Public Health Clinical Center Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengsong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Science Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13163959"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-022-01298-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2818"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007663"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.01.168"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-4683"},{"issue":"5","key":"e_1_2_11_8_1","first-page":"814","article-title":"PET in lung cancer","volume":"40","author":"Coleman R. 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