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However, limited research has been conducted on the role of m6A in coronary artery disease (CAD). We conducted methylated RNA immunoprecipitation sequencing and RNA sequencing to obtain a genome\u2010wide profile of m6A\u2010modified long noncoding RNAs (lncRNAs) in human coronary artery smooth muscle cells either exposed to oxidized low\u2010density lipoprotein treatment or not, and the characteristics of the expression profiles were explored using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses. The predictive effects of seven selected lncRNAs on CAD were evaluated in peripheral blood mononuclear cells (PBMCs). The differentially m6A\u2010modified and expressed lncRNAs related genes were predominantly enriched in small GTPase\u2010mediated signal transduction, ErbB signaling, and Rap1 signaling. Additionally, the expression levels of <jats:italic>uc003pes.1<\/jats:italic>, <jats:italic>ENST00000422847<\/jats:italic>, and <jats:italic>NR_110155<\/jats:italic> were significantly associated with CAD, with <jats:italic>uc003pes.1<\/jats:italic> identified as an independent risk factor and <jats:italic>NR_110155<\/jats:italic> as an independent protective factor for CAD. <jats:italic>NR_110155<\/jats:italic> and <jats:italic>uc003pes.1<\/jats:italic> in PBMCs have the potential to serve as biomarkers for predicting CAD.<\/jats:p>","DOI":"10.1002\/cbin.12224","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T05:12:30Z","timestamp":1721020350000},"page":"1664-1679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrated analysis of differentially m6A modified and expressed lncRNAs for biomarker identification in coronary artery 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