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During activation and response, T cells undergo a metabolic reprogramming that involves various metabolic pathways, with a predominant reliance on glycolysis to meet their increased energy demands and enhanced effector response. Recently, extracellular vesicles (EVs) known as exosomes have been recognized as crucial signaling mediators in regulating the tumor microenvironment (TME). Recent reports indicates that exosomes may transfer biologically functional molecules to the recipient cells, thereby facilitate cancer progression, angiogenesis, metastasis, drug resistance, and immunosuppression by reprogramming the metabolism of cancer cells. This study sought to enlighten possible involvement of cancer\u2010derived exosomes in CD8\u2009+\u2009T cell glucose metabolism and discover a regulated signalome as a mechanism of action. We observed reduction in glucose metabolism due to downregulation of AKT\/mTOR signalome in activated CD8\u2009+\u2009T cells after cancer derived exosome exposure. In\u2010vivo murine breast tumor studies showed better tumor control and antitumor CD8\u2009+\u2009T cell glycolysis and effector response after abrogation of exosome release from breast cancer cells. Summarizing, the present study establishes an immune evasion mechanism of breast cancer cell secreted exosomes that will act as a foundation for future precision cancer therapeutics.<\/jats:p>","DOI":"10.1002\/cbin.12241","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T16:09:33Z","timestamp":1726589373000},"page":"45-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Breast cancer cell derived exosomes reduces glycolysis of activated CD8\u2009+\u2009T cells in a AKT\u2010mTOR dependent manner"],"prefix":"10.1002","volume":"49","author":[{"given":"Abhishek","family":"Choudhury","sequence":"first","affiliation":[{"name":"Immunology Laboratory, Department of Zoology University of Calcutta Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumya","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Immunology Laboratory, Department 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