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However, the roles of ZNF655 in MM progression remains unclear. In this study, we aimed to explore the effects of ZNF655 on progression by detecting the alteration of the phenotypes and tumorigenesis induced by ZNF655 knockdown in MM. The expression level of ZNF655 in MM was clarified by real\u2010time quantitative polymerase chain reaction assays. Furthermore, loss\u2010of\u2010function assays in vitro and in vivo was investigated the biological functions of ZNF655 in MM. These findings revealed that ZNF655 depletion remarkably inhibited MM cell proliferation, arrested cell cycle, and induced cell apoptosis. Mechanistically, ZNF655 was found to regulate AKT in MM. In conclusion, this study indicated that ZNF655 regulated the progression of MM via AKT activation and downregulation of ZNF655 may be a promising antitumor strategy in MM.<\/jats:p>","DOI":"10.1002\/cbin.12256","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T06:11:50Z","timestamp":1730700710000},"page":"177-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ZNF655 involved in the progression of multiple myeloma via the activation of AKT"],"prefix":"10.1002","volume":"49","author":[{"given":"Haiming","family":"Kou","sequence":"first","affiliation":[{"name":"Department of Hematology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuqin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Nursing Zibo Vocational Institute 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