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Recently, more and more evidence indicated that phytochemicals, plant secondary metabolites, have numerous therapeutic functions against human diseases via affecting a variety of mechanisms with their distinct advantages of high efficiency and low toxicity. Here, we highlight the mechanisms of phytochemicals to hinder inflammation\u2010associated diseases (including Inflammatory diseases, cardiovascular diseases, metabolic syndrome, neurological disorders, skin diseases, respiratory diseases, kidney diseases, gastrointestinal diseases, retinal diseases, viral infections) by regulating the crosstalk among various signal cascades (including MicroRNAs, SIRT1, DNMTs, NF\u2010\u03baB, NLRP3, TGF\u2010\u03b2, the Gasdermin\u2010mediated pyroptosis pathway), which can be considered as a novel and potential therapeutic strategy. Furthermore, phytochemicals could prevent virus infection by disturbing different targets in the virus replication cycle. However, natural plants have shown limited bioavailability due to their low water solubility, the use of adjuvants such as liposomal phytochemicals, phytochemical nanoparticles and phytochemicals\u2010phospholipid complex promote their bioavailability to exhibit beneficial effects against various diseases. The purpose of this review is to explore the molecular mechanisms and promising applications of phytochemicals in the fields of inflammation\u2010associated diseases and virus infection to provide some direction.<\/jats:p>","DOI":"10.1002\/cbin.70011","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T05:55:51Z","timestamp":1742190951000},"page":"606-633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cellular and Molecular Mechanisms of Phytochemicals Against Inflammation\u2010Associated Diseases and Viral Infection"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1703-1500","authenticated-orcid":false,"given":"Zhaodi","family":"Zheng","sequence":"first","affiliation":[{"name":"College of Medical Imaging and Laboratory Jining Medical University Jining 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