{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:37:50Z","timestamp":1789749470993,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Piwei Peiyuan (PWPY) prescription is a traditional Chinese medicine prescription and has been efficiently used in the clinics to treat chronic atrophic gastritis (CAG) for many years. However, the mechanism of action underlying PWPY for treating CAG remains elusive. A CAG rat animal and cell model was constructed in this study to explore the action mechanism of PWPY prescription in treating CAG. Here we show that PWPY attenuates the progression of CAG by eliciting MAPK10\u2010mediated mitochondrial autophagy. Experimental model of CAG was introduced using\n                    <jats:italic>N<\/jats:italic>\n                    \u2010methyl\u2010n'\u2010nitro\u2010n\u2010nitroguanidine (MNNG). Our histological analyses reveal that MNNG\u2010induced CAG in rat undergoes classical morphological alterations judged by immunohistochemistry and serum level of PG\u2160, PG\u2161, and G17. Importantly, PWPY treatment prevents the progression of MNNG\u2010induced CAG judged by serum level of PG\u2160, PG\u2161, and G17. Interestingly, PWPY treatment inhibits MAPK10 activity judged by biochemical assays and promotes mitochondrial autophagy judged by electron microscopic analyses. Thus, we conclude that PWPY attenuates the progression of MNNG\u2010induced CAG and prevents precancerous lesions by harnessing MAPK10\u2010elicited mitochondrial autophagy. The MNNG\u2010induced experimental CAG model provides a robust platform for further delineating therapeutic targets underlying PWPY regimen.\n                  <\/jats:p>","DOI":"10.1002\/cbin.70016","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T02:25:01Z","timestamp":1742351101000},"page":"692-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Piwei Peiyuan Prescription Attenuates the Progression of Chronic Atrophic Gastritis by Eliciting MAPK10\u2010Mediated Mitochondrial Autophagy"],"prefix":"10.1002","volume":"49","author":[{"given":"Yi","family":"Zhang","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Pei","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Sun","sequence":"additional","affiliation":[{"name":"The Department of Spleen and Stomach Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Research Department Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yang","sequence":"additional","affiliation":[{"name":"The Department of Spleen and Stomach Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueping","family":"Jin","sequence":"additional","affiliation":[{"name":"The Department of Spleen and Stomach Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"The Department of Spleen and Stomach Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2139-9554","authenticated-orcid":false,"given":"Xuejun","family":"Li","sequence":"additional","affiliation":[{"name":"The Department of Spleen and Stomach Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1226652"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27185828"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.733979"},{"issue":"24","key":"e_1_2_12_6_1","first-page":"6735","article-title":"Human Gastric Carcinogenesis: A Multistep and Multifactorial Process\u2010\u2010First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention","volume":"52","author":"Correa P.","year":"1992","journal-title":"Cancer Research"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.01.004"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01684-z"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2024.05.007"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040857"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116345"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155739"},{"key":"e_1_2_12_13_1","volume-title":"StatPearls. 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