{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:37:27Z","timestamp":1786977447745,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC) are chronic recurrent nonspecific intestinal disease. Current IBD therapeutics cannot fundamentally change the natural course of IBD. Therefore, it is of great significance to find new treatment strategies for IBD. Preclinical and clinical studies have shown that mesenchymal stem cells (MSCs) are a promising therapeutic approach. However, the mechanism by which MSCs alleviate colitis and how MSCs affect intestinal mucosal barrier is still unclear. LPS\u2010exposed human colonic epithelial cancer cell lines Caco2 and HT29. Dextran sulfate sodium (DSS)\u2010induced IBD mouse were treated with MenSCs. We found that LPS downregulates intercellular junction proteins and induces the production of inflammatory cytokines in intestinal epithelial cells. MenSCs reduced paracellular permeability and restored barrier integrity in Caco2 cells. In Vivo, MenSCs mitigated DSS\u2010induced colitis in mice by reducing body weight loss, colonic shortening, and disease activity index scores and by inhibiting the expressions of the pro\u2010inflammatory cytokines IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1. MenSCs increased the expression of TJ proteins, improved the destruction of tight junction (TJ) structures, and reduced intestinal epithelial permeability. Furthermore, MenSCs could inhibit NF\u2010\u03baB p65 phosphorylation and the expression of Snail and prevent Snail nuclear localization, thereby maintaining tight and adherens junctions. Our findings demonstrate that MenSCs alleviate intestinal inflammation and enhance barrier function by suppressing the NF\u2010\u03baB\/Snail signaling axis, offering a promising therapeutic strategy for inflammatory bowel diseases.<\/jats:p>","DOI":"10.1002\/cbin.70040","type":"journal-article","created":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T06:48:43Z","timestamp":1749278923000},"page":"1128-1140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Menstrual Blood\u2011Derived Endometrial Stem Cells Protect the Integrity of the Intestinal Barrier by Inhibiting the NF\u2010\u03baB\/Snail Signaling Pathway"],"prefix":"10.1002","volume":"49","author":[{"given":"Tao","family":"Ruan","sequence":"first","affiliation":[{"name":"Stem Cell and Biotherapy Engineering Research Center of Henan, College of Life Science and Technology Xinxiang Medical University Xinxiang China"},{"name":"Henan Joint International Research Laboratory of Stem Cell Medicine, School of Medical Engineering Xinxiang Medical University Xinxiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Han","sequence":"additional","affiliation":[{"name":"Henan Joint International Research Laboratory of Stem Cell Medicine, School of Medical Engineering Xinxiang Medical University Xinxiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxu","family":"Xue","sequence":"additional","affiliation":[{"name":"Stem Cell and Biotherapy Engineering Research Center of Henan, College of Life Science and Technology Xinxiang Medical University Xinxiang China"},{"name":"Henan Joint International Research Laboratory of Stem Cell Medicine, School of Medical Engineering Xinxiang Medical University Xinxiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Public Health Xinxiang Medical University Xinxiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9300-1771","authenticated-orcid":false,"given":"Juntang","family":"Lin","sequence":"additional","affiliation":[{"name":"Henan Joint International Research Laboratory of Stem Cell Medicine, School of Medical Engineering Xinxiang Medical University Xinxiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2020.01.007"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/636419"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13615"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-014-0189-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00224"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2002697"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.952071"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01797-y"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114306"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e06-09-0872"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336918.2016.1259058"},{"key":"e_1_2_11_13_1","first-page":"406","article-title":"Efficacy and Safety of Dual Biologic Therapy in Patients With Inflammatory Bowel Disease: A Review of the Literature","volume":"17","author":"Gold S. L.","year":"2021","journal-title":"Gastroenterology & Hepatology"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00766-3"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2012.2200"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00389"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.08.011"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjac040"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10209"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3182699072"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.10.001"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.007"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-023-03330-7"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00080"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13211"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03019-2"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02566"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-5-57"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300045"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01004"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3608"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113399"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8020193"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.186"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-57070-6"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v14.i1.104"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew235"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i15.2068"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-32-62"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5527935"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605530"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-03118-1"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1957-7"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05580-z"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-03177-4"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-013-0042-4"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.70040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T07:12:19Z","timestamp":1754982739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.70040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,7]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/cbin.70040"],"URL":"https:\/\/doi.org\/10.1002\/cbin.70040","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,7]]},"assertion":[{"value":"2024-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}