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SLAMF5, also known as CD84, has drawn increasing attention in cancer immunology due to its involvement in both tumor progression and immune modulation. This review explores the expression patterns, signaling mechanisms, and functional roles of SLAMF5\/CD84 within the tumor microenvironment. SLAMF5\/CD84 is expressed on multiple immune cell types and contributes to immune evasion by enhancing regulatory B cell function, promoting myeloid\u2010derived suppressor cell expansion, and upregulating immune checkpoint molecules such as PD\u2010L1. Its expression has been implicated in various hematologic malignancies and solid tumors, including chronic lymphocytic leukemia, multiple myeloma, and triple\u2010negative breast cancer. Emerging therapeutic approaches targeting SLAMF5\/CD84\u2014such as monoclonal antibodies and CAR T\u2010cell therapies\u2014offer promising strategies to counteract immunosuppression and improve treatment outcomes. By highlighting recent findings and therapeutic developments, this review underscores the significance of SLAMF5\/CD84 as both a prognostic biomarker and a novel target in cancer immunotherapy. Understanding SLAMF5\/CD84's multifaceted roles in the tumor immune landscape could support the development of more effective and personalized cancer treatment strategies.<\/jats:p>","DOI":"10.1002\/cbin.70074","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T11:11:09Z","timestamp":1755947469000},"page":"1379-1394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring SLAMF5\/CD84 in Cancer: Advancing the Frontiers of Tumor Immunology"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2021-4450","authenticated-orcid":false,"given":"Safia Obaidur","family":"Rab","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Science King Khalid University Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed 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