{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T21:25:51Z","timestamp":1768598751589,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The importance of co\u2010infections is not yet completely understood, and the impact and direction of their effects vary considerably. This study aimed to evaluate the role of total saline extract (TS) and excretory\/secretory (ES) products of\n                    <jats:italic>Strongyloides venezuelensis<\/jats:italic>\n                    filarioid larvae on a maternal\u2010interface cell model during\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    infection. BeWo cells were cultured and stimulated with TS antigens and ES products to evaluate their effects on cell viability,\n                    <jats:italic>T. gondii<\/jats:italic>\n                    proliferation, and cytokine production. Both TS and ES had no impact on BeWo cell viability and\n                    <jats:italic>T. gondii<\/jats:italic>\n                    proliferation. However, stimulation with the highest concentration of TS resulted in increased IL\u20104 production. Additionally, IL\u20106 levels significantly increased after\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection in all ES\u2010treated conditions. Increased IL\u20104 and IL\u20106 production was observed in comparison to the untreated control group (C) and\/or between infected and uninfected cells under the same antigenic stimulation. Moreover, MIF levels increased consistently after\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection, regardless whether antigenic stimulation was present. Our results show that\n                    <jats:italic>S. venezuelensis<\/jats:italic>\n                    antigens can influence the host immune environment, altering the secretion profile of IL\u20104 and IL\u20106 in BeWo cells, thereby highlighting the complexity of the helminth and protozoan interaction. These studies are essential for a comprehensive understanding of responses in strongyloidiasis and their possible implications for\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection and disease control strategies.\n                  <\/jats:p>","DOI":"10.1002\/cbin.70117","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T10:12:31Z","timestamp":1765879951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Strongyloides<\/i>\n                    Antigens Alter Cytokines Responses in\n                    <i>Toxoplasma gondii<\/i>\n                    \u2010Infected BeWo Trophoblast Cells"],"prefix":"10.1002","volume":"50","author":[{"given":"Fab\u00edola Teixeira","family":"Alves","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Diagn\u00f3stico de Parasitoses, Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal de Uberl\u00e2ndia  Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhrenda Carolliny Guardieiro","family":"Jesus","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Diagn\u00f3stico de Parasitoses, Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal de Uberl\u00e2ndia  Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eduarda Silva","family":"Diniz","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Diagn\u00f3stico de Parasitoses, Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal de Uberl\u00e2ndia  Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana Carvalho","family":"Luz","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunofisiologia da Reprodu\u00e7\u00e3o, Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal de Uberl\u00e2ndia  Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila Silva","family":"Franco","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Diagn\u00f3stico de Parasitoses, Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal de Uberl\u00e2ndia  Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa da Silva","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Diagn\u00f3stico de Parasitoses, Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal de Uberl\u00e2ndia  Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson Fernando Goulart","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Diagn\u00f3stico de Parasitoses, Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal de Uberl\u00e2ndia  Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bellisa Freitas","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunofisiologia da Reprodu\u00e7\u00e3o, Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal de Uberl\u00e2ndia  Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique Tomaz","family":"Gonzaga","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Diagn\u00f3stico de Parasitoses, Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal de Uberl\u00e2ndia  Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.575197"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aan2946"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.10.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12811"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.124115"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.12.013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182016000111"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9060468"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00033-23"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2017.07.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2025.107353"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-024-06401-7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.18502\/ijpa.v18i2.13183"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01236-07"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2022.102226"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005692"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2021.101544"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2003.08.007"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpara.2023.1197956"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00340"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1243480"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2011.01.016"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/RRTM.S282268"},{"key":"e_1_2_9_26_1","unstructured":"World Health Organization. \u201cGlobal Health Estimates 2016: Deaths by Cause Age Sex by Country and by Region 2000\u20132016.\u201d2016."},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082711"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1432-6"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.70117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbin.70117","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.70117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:16:00Z","timestamp":1768551360000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.70117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,16]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/cbin.70117"],"URL":"https:\/\/doi.org\/10.1002\/cbin.70117","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,16]]},"assertion":[{"value":"2025-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70117"}}