{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T17:00:44Z","timestamp":1773853244727,"version":"3.50.1"},"reference-count":163,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by sustained synovial inflammation contributing to bone erosion and loss of joint function. The pathological response of infiltrated T cell subsets, followed by the formation of ectopic lymphoid microstructures in the synovial tissue, promotes RA progression and exacerbates disease severity. Two major hallmarks of RA pathogenesis are dysregulated peripheral tolerance and aberrant pro\u2010inflammatory responses due to the secretion of pro\u2010inflammatory cytokines within the RA synovium. Interestingly, regulatory T cells (Tregs) and Th2, which play a vital role in maintaining immune homeostasis and peripheral tolerance, are reduced in numbers or become functionally impaired within the RA synovium, resulting in Th1\/Th2 and Th17\/Treg imbalance. Additionally, CD8+ T cells have also emerged as major mediators of synovial inflammation and autoantibody production in RA. Women display higher susceptibility to developing RA, and the chances of disease pathogenesis increase steadily from menarche to menopause, possibly due to a decline in sex\u2010hormone levels. Although the decline in female sex hormones has been implicated in aberrant T cell responses and RA progression, the impact of hormone levels on the molecular signaling pathways regulating T cell differentiation and homeostasis, and subsequently the disease pathogenesis in premenopausal and postmenopausal women, remains incompletely understood. Hence, this review aims to provide a comprehensive understanding of the differential control of sex hormone levels in regulating T cell responses, including T cell plasticity and functions associated with RA progression. We further discuss the underlying signaling mechanisms where declining postmenopausal sex\u2010hormone levels promote aberrant T\u2010cell activation and effector functions within the RA synovium, thereby disrupting peripheral tolerance and immune homeostasis, and contributing to RA pathogenesis. A critical understanding of sex hormone\u2010mediated regulation of T cell responses associated with RA may unveil novel hormone\u2010targeted therapeutic strategies to limit disease progression.<\/jats:p>","DOI":"10.1002\/cbin.70150","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:44:42Z","timestamp":1773060282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex Hormones Regulate T\u2010Cell Responses Associated With Rheumatoid Arthritis"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2705-3343","authenticated-orcid":false,"given":"Soham","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Department of Life Science &amp; Biotechnology Jadavpur University Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debajyoti","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Life Science &amp; Biotechnology Jadavpur University Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sougata Roy","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Life Science &amp; Biotechnology Jadavpur University Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/joe-23-0398"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2024.104295"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-020-02349-y"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.11.009"},{"issue":"8","key":"e_1_2_12_6_1","first-page":"1254","article-title":"The Role of Female Hormonal Factors in the Development of Rheumatoid Arthritis","volume":"56","author":"Alp\u00edzar\u2010Rodr\u00edguez D.","year":"2017","journal-title":"Rheumatology (Oxford, England)"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.04.034"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0548-y"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2006.07.001"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1993.1026"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20140712"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86800"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237222"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.12.862"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.33696\/immunology.7.232"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801403"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2010.28"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.040577497"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12398"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38941"},{"issue":"12","key":"e_1_2_12_21_1","first-page":"2597","article-title":"Increased Estrogen Formation and Estrogen to Androgen Ratio in the Synovial Fluid of Patients With Rheumatoid Arthritis","volume":"30","author":"Castagnetta L. A.","year":"2003","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci11066"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00353"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/535361"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1154575"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70174-5"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2804"},{"issue":"6","key":"e_1_2_12_28_1","first-page":"687","article-title":"New Roles for Estrogens in Rheumatoid Arthritis","volume":"21","author":"Cutolo M.","year":"2003","journal-title":"Clinical and Experimental Rheumatology"},{"issue":"3","key":"e_1_2_12_29_1","first-page":"iii2","article-title":"Oestrogens in Rheumatic Diseases: Friend or Foe?","volume":"47","author":"Cutolo M.","year":"2008","journal-title":"Rheumatology"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04210.x"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaf159"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203304lu1094oa"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70171-X"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.04.003"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-07-0317"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00075"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01903"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1838"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.1998.540417.x"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2019.03.001"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.146.12.4362"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02740"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-009-0052-y"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.05.025"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404888101"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-003-0760-3"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.09.003"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008-0017"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611514104"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801458"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207459008999730"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(01)00034-0"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00794"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200009)30:9<2586::AID-IMMU2586>3.0.CO;2-L"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.208.Supp.55.21"},{"issue":"2","key":"e_1_2_12_56_1","first-page":"1233","article-title":"Disrupted Th1\/Th2 Balance in Patients With Rheumatoid Arthritis (RA)","volume":"10","author":"He C.","year":"2017","journal-title":"International Journal of Clinical & Experimental Pathology"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.672168"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.10.008"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.12.003"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.144"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1012491"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24548"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.03.111"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3238"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2021.101729"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/350209"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1140"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0832"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2006.08.005"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(01)00117-6"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/317452"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040303"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402468111"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2017.10.002"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-017-9704-1"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.2.819"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2015.09.010"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2022.114034"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.07.008"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.9.5716"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2011.11.002"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142317"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003919"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)02165-5"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2255"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.26"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201445404"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.08.038"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.54"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.117.Bjr-2021-0594.R1"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.18.2266"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-12495-9"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/immu.200310027"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/593493"},{"issue":"3","key":"e_1_2_12_95_1","first-page":"185","article-title":"The Effect of Estradiol, but Not Progesterone, on the Production of Cytokines in Stimulated Whole Blood, Is Concentration\u2010Dependent","volume":"24","author":"Matalka K. Z.","year":"2003","journal-title":"Neuro Endocrinology Letters"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2016.02.010"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1991.tb05679.x"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2001.0900"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874279300903010061"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1108856108"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100670070029"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.3.1087"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aap9415"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000125"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4545"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802611796117630"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.51287"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02279"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9788"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41927-024-00418-2"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2665-9913(20)30344-1"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1016263"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00493"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2024.13339"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-015-0004-y"},{"issue":"2","key":"e_1_2_12_116_1","first-page":"205","article-title":"Sex\u2010Based Differences in Autoimmune Diseases","volume":"52","author":"Ortona E.","year":"2016","journal-title":"Annali dell'Istituto superiore di sanita"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-007-0072-5"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/207403"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328277ef2a"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.23.1.0456"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.1.128"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.08.023"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.909879"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.03.006"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040395"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2012.02.023"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.689698"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.93371"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1995.tb00907.x"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab101"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(02)02967-9"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1769"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12215"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901942"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81380-8"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38871"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci68140"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.930227"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1056"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201243218"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0001"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.01.006"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-009-0472-4"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1997.tb00321.x"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21221"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201542"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.02.004"},{"issue":"2","key":"e_1_2_12_148_1","first-page":"1068","article-title":"Changes in Peripheral Blood T Lymphocyte Subsets Predict Disease Progression in Patients With Rheumatoid Arthritis","volume":"14","author":"Tan J.","year":"2022","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2020.1771183"},{"issue":"11","key":"e_1_2_12_150_1","first-page":"2338","article-title":"Abnormal Levels of Serum Dehydroepiandrosterone, Estrone, and Estradiol in Men With Rheumatoid Arthritis: High Correlation Between Serum Estradiol and Current Degree of Inflammation","volume":"30","author":"Tengstrand B.","year":"2003","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.154818"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21674-6"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044552"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.301223.eaf"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1997.1227"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1080\/08830185.2019.1621865"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14-08-1323"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1169232"},{"key":"e_1_2_12_159_1","first-page":"10","article-title":"Adrenal and Gonadal Steroid Hormone Deficiency in the Pathogenesis of Rheumatoid Arthritis","volume":"44","author":"Wilder R. L.","year":"1996","journal-title":"The Journal of Rheumatology. Supplement"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3819"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.10.029"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-92150-1"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1957"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11350"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.70150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbin.70150","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.70150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:33:19Z","timestamp":1773829999000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.70150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":163,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/cbin.70150"],"URL":"https:\/\/doi.org\/10.1002\/cbin.70150","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70150"}}