{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T08:08:10Z","timestamp":1779178090591,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["434204\/2018\u20108"],"award-info":[{"award-number":["434204\/2018\u20108"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307974\/2019\u20107"],"award-info":[{"award-number":["307974\/2019\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Human dental pulp stem cells (DPSCs) exhibit neurogenic differentiation potential; however, inflammatory conditions may impair this process. This study investigated the impact of tumor necrosis factor alpha (TNF\u2010\u03b1) on the neurodifferentiation potential of DPSCs and the modulatory role of the pro\u2010resolving lipid mediators lipoxin A4 (LXA4) and resolvin D1 (RvD1). DPSCs were isolated and subjected to neuronal differentiation for 21 days. Cells were treated with different concentrations of TNF\u2010\u03b1 (1, 10, 25, and 100\u2009ng\/mL) and with LXA4 or RvD1 (10 and 100\u2009nM). After 21 days, neuronal differentiation was associated with a reduction in the stem cell marker OCT3\/4 (53% in the absence of TNF\u2010\u03b1 and 48.5% in the presence of TNF\u2010\u03b1) and increased expression of the early neuronal marker doublecortin (87% in the absence of TNF\u2010\u03b1 and 116% in the presence of TNF\u2010\u03b1). The intermediate neuronal marker \u03b2III\u2010tubulin increased by 135% in the absence of TNF\u2010\u03b1 but decreased by 40% in its presence. The reduction in \u03b2III\u2010tubulin induced by 25\u2009ng\/mL TNF\u2010\u03b1 was partially attenuated by treatment with 100\u2009nM RvD1 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02) or 10\u2009nM LXA4 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). These findings suggest that LXA4 and RvD1 help preserve the neural differentiation potential of DPSCs cultured under inflammatory conditions.\n                  <\/jats:p>","DOI":"10.1002\/cbin.70163","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:05:08Z","timestamp":1779174308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipoxin A4 and Resolvin D1 Preserve Neural Inductive Capacity of Dental Pulp Stem Cells Cultured Under Inflammatory Conditions"],"prefix":"10.1002","volume":"50","author":[{"given":"Ana Paula","family":"Turrioni","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry and Orthodontics, School of Dentistry Federal University of Uberlandia Uberlandia Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6180-3084","authenticated-orcid":false,"given":"Geovana Pires","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry and Orthodontics, School of Dentistry Federal University of Uberlandia Uberlandia Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"ADA Forsyth Institute Somerville Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alpdogan","family":"Kantarci","sequence":"additional","affiliation":[{"name":"ADA Forsyth Institute Somerville Massachusetts USA"},{"name":"University of Minnesota Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4395-3958","authenticated-orcid":false,"given":"Hatice","family":"Hasturk","sequence":"additional","affiliation":[{"name":"ADA Forsyth Institute Somerville Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo A.","family":"Battaglino","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Miller School of Medicine University of Miami Coral Gables Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie R.","family":"Morse","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Miller School of Medicine University of Miami Coral Gables Florida 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