{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:28:34Z","timestamp":1787059714608,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diabetic nephropathy (DN) is a one of the common microvascular complication of diabetes that involves oxidative stress, inflammation, activation and overexpression of Nuclear factor kappa B (NF\u2010\u03baB), and chronic renal dysfunction. In this study, we evaluated the renoprotective role of perillaldehyde (PA) in protecting kidneys from diabetic nephropathy using in vitro and in vivo models of Streptozotocin\u2010induced diabetic nephropathy. PA pre\u2010treatment of NRK\u201052E cells under high\u2010glucose conditions resulted in a significant reduction of reactive oxygen species formation, up\u2010regulation of nuclear factor erythroid 2\u2010related factor 2 (Nrf2), suppression of Kelch\u2010like ECH\u2010associated protein 1 (Keap1), and elevation of antioxidant enzyme biomarkers, such as heme oxygenase 1, superoxide dismutase 1, and NAD(P)H dehydrogenase quinone 1. PA also inhibited the overexpression of NF\u2010\u03baB, inducible nitric oxide synthase, and poly (ADP\u2010ribose) polymerase in high\u2010glucose exposed NRK\u201052E cells. Administration of PA (35 and 70\u2009mg\/kg) to streptozotocin\u2010induced diabetic rats showed beneficial effects on renal function parameters such as creatinine and blood urea nitrogen. PA treatment attenuated glomerular and tubular structural damage, as evidenced by H&amp;E and PAS staining. At molecular level, PA was found to maintain the redox balance in the kidneys by stimulating the Nrf2\/Keap1\/HO\u20101 signalling pathway and inhibiting the NF\u2010\u03baB\u2010dependent inflammatory response. Moreover, PA lowered lipid peroxidation and enhanced antioxidant status via reduction in MDA and elevation in GSH. The above results indicated that PA showed considerable reno\u2010protective actions through coordinated regulation of both oxidative stress and inflammation pathways in experimental models of diabetic nephropathy<\/jats:p>","DOI":"10.1002\/cbin.70193","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T11:47:12Z","timestamp":1786016832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perillaldehyde Attenuates Diabetic Nephropathy through Modulation of the Nrf2\/Keap1 and NF\u2010\u03baB Signalling Pathways"],"prefix":"10.1002","volume":"50","author":[{"given":"Harini","family":"Ramachandran","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash Kumar","family":"Mourya","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER) SAS Nagar Mohali India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6659-4751","authenticated-orcid":false,"given":"Ashutosh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad India"},{"name":"Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER) SAS Nagar Mohali India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2025.05.007"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12393"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.130.4.1910"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2018.02.010"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108397"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10010039"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2008.09.017"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600511113"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27113578"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12051098"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.07.009"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12040542"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076053"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70268"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2025.111784"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01914-4"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2025.124038"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.1568"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-009-0128-1"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2007.00855.x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.63.s83.20.x"},{"key":"e_1_2_12_23_1","unstructured":"Rout P. andI.Jialal(2026). 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