{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:28:33Z","timestamp":1787059713899,"version":"build-2736575974"},"reference-count":61,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574977"],"award-info":[{"award-number":["82574977"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic atrophic gastritis (CAG) with intestinal metaplasia (IM) is a key precancerous lesion that may progress to intestinal\u2010type gastric adenocarcinoma. Piwei Peiyuan Pill (PPP) has shown significant clinical efficacy in ameliorating CAG with IM, but its active components and underlying mechanisms remain unclear. High\u2010performance liquid chromatography (HPLC) and ultra\u2010high performance liquid chromatography coupled with high\u2010resolution mass spectrometry (UHPLC\u2010HRMS) were used to identify the components of PPP and the active ingredients in PPP\u2010containing serum. The therapeutic efficacy and potential mechanisms of PPP were further investigated via transcriptomic sequencing and experimental validation. UHPLC\u2010HRMS analysis of PPP\u2010containing serum identified several bioactive components, including esculin, lithospermic acid, and atractylenolide III. In CAG rats, PPP significantly ameliorated gastric mucosal damage and reduced serum IL\u20106 and TNF\u2010\u03b1 levels. Transcriptomic results showed that IRAK1 was highly expressed in CAG patients with IM and associated with activation of the NF\u2010\u03baB pathway. PPP intervention dose\u2010dependently suppressed hyperactivation of the Pellino1\/IRAK1\/NF\u2010\u03baB axis and decreased the expression of intestinal metaplasia markers CDX1 and MUC2. Additionally, PPP improved immune function by increasing the proportion of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells and decreasing the proportion of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in CAG model rats. Taken together, these findings suggest that PPP mitigates CAG and attenuates IM at least in part by suppressing the Pellino1\/IRAK1\/NF\u2010\u03baB signaling pathway, indicating that it may serve as a promising therapeutic strategy for reducing inflammation\u2010associated gastric carcinogenesis.\n                  <\/jats:p>","DOI":"10.1002\/cbin.70195","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T12:48:21Z","timestamp":1786538901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Piwei Peiyuan Pill Ameliorates Chronic Atrophic Gastritis and Intestinal Metaplasia at Least in Part by Inhibiting the Pellino1\/IRAK1\/NF\u2010\u03baB Signaling Axis"],"prefix":"10.1002","volume":"50","author":[{"given":"Cheng","family":"Zhang","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Anhui University of Chinese Medicine Hefei Anhui 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