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In this study, lesion\u2010derived amastigotes exhibited differential protein expression in a host\u2010dependent manner. Herein, we evaluate the impact of the immune system of these two mouse strains on parasite survival and virulence. For this, BALB\/c and BALB\/c\n                    <jats:sup>nu\/nu<\/jats:sup>\n                    mice were infected with promastigotes of the LV79 strain, and after 13\u2010weeks of infection, amastigotes were isolated from the lesion footpads. The amastigotes recovered from BALB\/c mice were more viable, generating cultures with a higher number of promastigotes than those from BALB\/c nude mice. Accordingly, lesion\u2010derived amastigotes from BALB\/c mice displayed higher infectivity, induced larger parasitophorous vacuoles in vitro, and exhibited greater virulence in vivo than those from BALB\/c\n                    <jats:sup>nu\/nu<\/jats:sup>\n                    mice. These findings demonstrate that the mouse immune environment can shape the biological phenotype of the parasite, directly impacting its survival and virulence.\n                  <\/jats:p>","DOI":"10.1002\/cbin.70197","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:34:34Z","timestamp":1786541674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Murine T Cell\u2010Dependent Response Affects\n                    <i>Leishmania amazonensis<\/i>\n                    Amastigote Survival and Virulence"],"prefix":"10.1002","volume":"50","author":[{"given":"Gustavo Henrique Corr\u00eaa","family":"Soares","sequence":"first","affiliation":[{"name":"Departamento de Parasitologia, Instituto de Ci\u00eancias Biom\u00e9dicas Universidade de S\u00e3o Paulo S\u00e3o Paulo Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo 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