{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:34:12Z","timestamp":1793255652622,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2025AFC043"],"award-info":[{"award-number":["2025AFC043"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2024AFB470"],"award-info":[{"award-number":["2024AFB470"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Keloids are intricate fibroproliferative disorders characterized by sustained fibroblast activation, excessive deposition of extracellular matrix, and dysregulated wound\u2010healing responses. This study explored the therapeutic effects and underlying mechanisms of Isoginkgetin (IGK) in keloid fibroblasts (KFbs) and a human keloid xenograft model. Our findings indicated that MDM2 expression was elevated in clinical keloid specimens, and IGK treatment inhibited KFbs proliferation and migration while inducing cell cycle arrest and apoptosis. Mechanistically, IGK downregulated MDM2 expression at the transcriptional level and was associated with the modulation of the MDM2\/p53 signaling axis. LiP\u2010MS and molecular docking analyses identified eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) as a potential IGK\u2010associated protein, suggesting that EEF1A1 may play a role in IGK\u2010mediated regulation of MDM2 expression. Moreover, transcriptomic analysis of xenograft tissues combined with serum multicytokine profiling demonstrated that IGK treatment modulated inflammation\u2010associated signatures, including those related to TNF signaling pathways, within the xenograft model. In vivo, administration of IGK resulted in a reduction in volume, collagen deposition, and \u03b1\u2010SMA expression in established human keloid xenografts. Taken together, these findings indicate that IGK exerts anti\u2010keloid effects by modulating the MDM2\/p53 signaling axis and inflammation\u2010associated pathways, underscoring its potential as a therapeutic candidate for keloid treatment.<\/jats:p>","DOI":"10.1002\/cbin.70213","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:50:57Z","timestamp":1790247057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["IGK Suppresses Keloid Fibroblast Activation Through Modulation of MDM2 Expression and p53 Signaling"],"prefix":"10.1002","volume":"50","author":[{"given":"Ziqing","family":"Ye","sequence":"first","affiliation":[{"name":"Institute of Burns Wuhan Third Hospital (Tongren Hospital of WuHan University) Wuhan China"},{"name":"Hubei Provincial Clinical Medical Research Center for Burns Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Burns Wuhan Third Hospital (Tongren Hospital of WuHan University) Wuhan China"},{"name":"Hubei Provincial Clinical Medical Research Center for Burns Wuhan China"},{"name":"Second Clinical College Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huancheng","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Urology Wuhan Third Hospital (Tongren Hospital of WuHan University) Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Burns Wuhan Third Hospital (Tongren Hospital of WuHan University) Wuhan China"},{"name":"School of Medicine Wuhan University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0088-6177","authenticated-orcid":false,"given":"Shuhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Burns Wuhan Third Hospital (Tongren Hospital of WuHan University) Wuhan China"},{"name":"Hubei Provincial Clinical Medical Research Center for Burns Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongfang","family":"Ruan","sequence":"additional","affiliation":[{"name":"Institute of Burns Wuhan Third Hospital (Tongren Hospital of WuHan University) Wuhan China"},{"name":"Hubei Provincial Clinical Medical Research Center for Burns Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-5896","authenticated-orcid":false,"given":"Junhui","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Burns Wuhan Third Hospital (Tongren Hospital of WuHan University) Wuhan China"},{"name":"Hubei Provincial Clinical Medical Research Center for Burns Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maolong","family":"Dong","sequence":"additional","affiliation":[{"name":"Institute of Burns Wuhan Third Hospital (Tongren Hospital of WuHan University) Wuhan China"},{"name":"Hubei Provincial Clinical Medical Research Center for Burns Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Xie","sequence":"additional","affiliation":[{"name":"Institute of Burns Wuhan Third Hospital (Tongren Hospital of WuHan University) Wuhan China"},{"name":"Hubei Provincial Clinical Medical Research Center for Burns Wuhan China"},{"name":"Second Clinical College Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8177-8919","authenticated-orcid":false,"given":"Siyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Burns Wuhan Third Hospital (Tongren Hospital of WuHan University) Wuhan China"},{"name":"Hubei Provincial Clinical Medical Research Center for Burns Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prmcm.2023.100331"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-026-02975-6"},{"issue":"2","key":"e_1_2_10_4_1","first-page":"33","article-title":"Keloids: A Review of Etiology","volume":"13","author":"Betarbet U.","year":"2020","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","unstructured":"Chagas M. M. D.Behrens andC. J.Moragas\u2010Tellis.2022. Flavonols and Flavones as Potential Anti\u2010inflammatory Antioxidant and Antibacterial Compounds.9966750.","DOI":"10.1155\/2022\/9966750"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2013.1303"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-08-0661"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105273"},{"issue":"1","key":"e_1_2_10_9_1","article-title":"Tumor Suppressor p53: Biology, Signaling Pathways, and Therapeutic Targeting, Biochimica Et Biophysica Acta","volume":"1876","author":"Hern\u00e1ndez Borrero L. J.","year":"2021","journal-title":"Reviews on Cancer"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-12-0425"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111579"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1302"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","unstructured":"Li X. Y.Zhai B.Xi et al. Pinocembrin Ameliorates Skin Fibrosis via Inhibiting tgf\u2010\u03b21 Signaling Pathway 11(2021) no.8.","DOI":"10.3390\/biom11081240"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00360"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14097"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1941710"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","unstructured":"Noor E. T. andR.Das.2022. Ginkgo Biloba: A Treasure of Functional Phytochemicals With Multimedicinal Applications.8288818.","DOI":"10.1155\/2022\/8288818"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.86"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05174.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152009789124628"},{"issue":"10","key":"e_1_2_10_21_1","article-title":"Biflavonoids: Important Contributions to the Health Benefits of Ginkgo (Ginkgo biloba L.)","volume":"11","author":"\u0160amec D.","year":"2022","journal-title":"Plants (Basel, Switzerland)"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2023.01.002"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2024.105918"},{"issue":"1","key":"e_1_2_10_24_1","first-page":"11","article-title":"Hypertrophic Scars and Keloids: A Review and Current Treatment Modalities, Biomedical","volume":"4","author":"Tripathi S.","year":"2020","journal-title":"Dermatology"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.07.001"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063211"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-024-03356-8"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0321"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c02045"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmt147"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2021.119123"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.70213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbin.70213","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.70213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:45:40Z","timestamp":1793252740000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.70213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/cbin.70213"],"URL":"https:\/\/doi.org\/10.1002\/cbin.70213","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"assertion":[{"value":"2026-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70213"}}