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Although genetic studies have identified numerous hearing\u2010loss\u2010associated genes, the molecular changes accompanying noise\u2010induced hearing loss (NIHL) remain incompletely understood. We characterized the adult mouse cochlear proteome following damaging noise exposure using nano\u2010LC\u2013MS\/MS and an integrative bioinformatics workflow. Comparative profiling of normal\u2010hearing and NIHL cochleae identified 1742 proteins and an 80\u2010protein NIHL\u2010associated signature comprising 49 quantitatively defined differentially abundant proteins and 31 condition\u2010specific proteins. These proteins were organized into five functional groups encompassing metabolic and mitochondrial function, protein synthesis and ribonucleoprotein complexes, structural and synaptic organization, cell polarity and cytoskeletal remodeling, and regulatory and stress\u2010responsive functions. Representative alterations included reduced HSPA9, a mitochondrial chaperone involved in protein homeostasis; changes in the RNA\u2010associated proteins PRMT1 and CIRBP; reduced HAPLN1, associated with extracellular matrix organization; and altered MAP2K2, a signaling protein related to cell polarity; and increased SYNJ2. Comparison with an independent cochlear proteomic data set identified 39 of the 80 proteins as dysregulated, with 22 showing concordant directional changes. Single\u2010cell transcriptomic mapping provided cellular context for 74 of the 80 protein\u2010associated genes, while human genetic and disease annotations supported the prioritization of selected proteins associated with hearing or ear phenotypes. Together, these findings define a proteomic landscape of the noise\u2010exposed cochlea and identify molecular candidates and cellular processes for further investigation of NIHL.<\/jats:p>","DOI":"10.1002\/cbin.70218","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:49:00Z","timestamp":1790851740000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proteomic Signatures of Noise\u2010Induced Hearing Loss in the Mouse Cochlea"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4935-7687","authenticated-orcid":false,"given":"Ana Carla","family":"Batissoco","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Otorrinolaringologia\/LIM 32, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"ENT Department Hospital das Cl\u00ednicas da Faculdade de 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