{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:45:15Z","timestamp":1792147515965,"version":"4.4.0"},"reference-count":76,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Osteoarthritis (OA) is a multifactorial whole joint disease characterized by cartilage degeneration, subchondral bone remodeling, synovial inflammation, and progressive functional impairment. Increasing evidence suggests that OA is not simply a wear and tear disorder, but a mechanobiological disease in which abnormal mechanical stress interacts with inflammatory and metabolic pathways to drive joint degeneration. This review summarizes recent advances in the mechanobiology of OA, focusing on the interplay between mechanical stress, inflammation, and joint remodeling. We discuss the major mechanosensing and mechanotransduction mechanisms in chondrocytes, including primary cilia, integrins, the cytoskeleton, the LINC complex, and mechanosensitive ion channels such as TRPV4, TRPM7, and PIEZO channels. We further examine how these pathways regulate extracellular matrix homeostasis, chondrocyte fate, and the transition from anabolic maintenance to catabolic degeneration, as well as how altered joint loading affects subchondral bone remodeling through osteocyte responses, the RANK\/RANKL\/OPG axis, and Wnt\/\u03b2\u2010catenin signaling. Particular attention is given to the crosstalk between mechanotransduction and inflammatory signaling, including NF\u2010\u03baB, MAPK, and macrophage polarization pathways, which together amplify structural damage under pathological loading. Finally, we highlight emerging therapeutic strategies based on biomechanical modulation and mechano\u2010inflammatory targeting. A better understanding of these integrated mechanisms may provide new insight into OA pathogenesis and support the development of disease\u2010modifying therapies.<\/jats:p>","DOI":"10.1002\/cbin.70219","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:56:10Z","timestamp":1790686570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanobiology of Osteoarthritis: Interactions Between Mechanical Stress, Inflammation, and Joint Remodeling"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4179-1394","authenticated-orcid":false,"given":"Jiawei","family":"Shen","sequence":"first","affiliation":[{"name":"School of Rehabilitation Medicine Jiangsu Medical College Yancheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3324-3816","authenticated-orcid":false,"given":"Zelin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Palmer College of Chiropractic Port Orange Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Hang","family":"Yiu","sequence":"additional","affiliation":[{"name":"Jin Ji Jian Healthcare Co., Ltd Wuxi City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7781-7900","authenticated-orcid":false,"given":"Zhifei","family":"Xie","sequence":"additional","affiliation":[{"name":"Palmer College of Chiropractic Port Orange Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[{"name":"Palmer College of Chiropractic Port Orange Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3393-2579","authenticated-orcid":false,"given":"Shawn","family":"He","sequence":"additional","affiliation":[{"name":"Palmer College of Chiropractic Port Orange Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20601"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-022-02848-0"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514522485"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbmr\/zjae144"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-019-0197-9"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2165"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-024-00315-x"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.03.015"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09491-5"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S492415"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-006-0032-3"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12102292"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4725"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.006064"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.2490\/prm.20240025"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000068964.34812.2b"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.4.180102"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000144971.12731.a2"},{"key":"e_1_2_15_20_1","first-page":"587","article-title":"Shear and Compression Differentially Regulate Chondrocyte Biosynthesis via IL\u20101\u03b2\u2013dependent Pathways","volume":"39","author":"Fitzgerald J. 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