{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:48:45Z","timestamp":1792612125866,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007656","name":"Loyola University Chicago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007656","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatocellular carcinoma (HCC), a lethal form of liver cancer, continues to show rising mortality rates despite advancements in immunotherapies. This highlights the need for more effective treatments. Recent studies linked the presence of B cells within human tumors, including HCC, to improved responses to immunotherapy and better prognoses. Specifically, tumor\u2010infiltrating B cells have been associated with reduced cancer cell proliferation, suggesting that B cell\u2010mediated responses may be harnessed as a potential therapeutic strategy against HCC. However, in advanced HCC, IL\u201010\u2010producing regulatory B cells accumulate and promote tumor growth. These paradoxical findings on B cells in human HCC highlight the necessity for clarifying the specific functions of B cells in HCC development to develop B cell\u2010targeted therapies. To investigate the role of B cells in HCC, we used B cell\u2010deficient (muMT) mice and anti\u2010CD20 antibodies to deplete B cells in WT mice. In both systems, we observed a strong protection against liver tumor formation upon HCC induction, indicating the presence of a potent anti\u2010tumor effect in the absence of B cells before HCC induction. Additionally, depletion of B cells after tumor foci have formed in the liver at later stage of HCC also potently suppressed tumor growth. Functionally, depletion of CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells partially restored susceptibility to tumor growth, suggesting that B cell depletion suppresses HCC development partly through enhanced T cell\u2010mediated immunity. These findings reveal an underappreciated tumor\u2010suppressing effect of B cells in HCC and suggest that targeting the mechanisms of B cell suppression may boost anti\u2010tumor responses in HCC.\n                  <\/jats:p>","DOI":"10.1002\/cbin.70227","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:44:38Z","timestamp":1792233878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["B Cell Deficiency Protects Against\u00a0the Development of c\u2010MET and Beta\u2010Catenin Driven Hepatocellular Carcinoma in Mice"],"prefix":"10.1002","volume":"50","author":[{"given":"Fang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Loyola University Chicago Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Bi","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Loyola University Chicago Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehan","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Loyola University Chicago Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2693-6467","authenticated-orcid":false,"given":"Yee Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Loyola University Chicago Maywood Illinois 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