{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T10:10:59Z","timestamp":1697105459422},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,4,12]],"date-time":"2002-04-12T00:00:00Z","timestamp":1018569600000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of the present study was to determine whether postprocedural antithrombotic therapy with prolonged heparin infusion followed by 6 months of oral anticoagulation in addition to acetylsalicylic acid (ASA) reduces the incidence of angiographic restenosis after successful PTCA. One hundred ninety\u2010one patients with uncomplicated PTCA were randomized into two groups: one group was discharged with ASA 100 mg only (G1) and the other group was additionally treated with 12\u201324 hr of heparin infusion and overlapping oral anticoagulation with coumadin for 6 months (G2). The two groups were comparable with respect to age, gender, coronary risk profile, clinical presentation, and angiographic lesion characteristics. Stents were implanted in 33% and 36% of the G1 and G2 patients, respectively. In\u2010hospital myocardial infarction occurred in 4% of the G1 and 3% of the G2 patients. One patient in G1 died of subacute stent thrombosis (day 3). Six\u2010month angiographic follow\u2010up was obtained in 90% of G1 patients and 94% of G2 patients. Restenosis occurred in 30% and 33% of the patients and mean diameter stenoses at follow\u2010up were 40% \u00b1 28% and 39% \u00b1 24%, respectively. Thrombin inhibition with heparin infusion followed by 6 months of oral anticoagulation did not reduce angiographic restenosis among patients undergoing PTCA with or without stent implantation. The occurrence of acute ischemic complications was also comparable in the two groups. Cathet Cardiovasc Intervent 2002;55:315\u2013320. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.10084","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:24:15Z","timestamp":1030317855000},"page":"315-320","source":"Crossref","is-referenced-by-count":3,"title":["Heparin and coumadin versus acetylsalicylic acid for prevention of restenosis after coronary angioplasty"],"prefix":"10.1002","volume":"55","author":[{"given":"Ali Reza","family":"Garachemani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Fleisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy","family":"Pfiffner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Meier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,4,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199708073370601"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90442-1"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.23.10624"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)91043-H"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90368-9"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199111283252213"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041240105"},{"key":"e_1_2_5_9_2","first-page":"261","article-title":"Heparin inhibition of human vascular smooth muscle cell hyperplasia","volume":"11","author":"Chan P","year":"1992","journal-title":"Int Angiol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199712)173:3<371::AID-JCP9>3.0.CO;2-K"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00062-9"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/16.suppl_I.33"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90942-3"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90598-7"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408253310801"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408253310802"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.77.4.645"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198806303182603"},{"key":"e_1_2_5_19_2","first-page":"201","article-title":"Review of antiplatelet drug use in preventing restenosis following percutaneous transluminal coronary angioplasty","volume":"4","author":"Cox JL","year":"1988","journal-title":"Can J Cardiol"},{"key":"e_1_2_5_20_2","first-page":"366","article-title":"The effects of ticlopidine administration at low doses on the incidence of restenosis following percutaneous transluminal coronary angioplasty","volume":"44","author":"Iniguez Romo A","year":"1991","journal-title":"Rev Esp Cardiol"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.11.3194"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199706123362401"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(98)90279-7"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.6.581"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00277-4"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003920050097"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199509213331203"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.69.4.721"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(89)90612-1"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.60.6.485"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.4.2070"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)80015-9"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.8.2140"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.10084","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.10084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T04:56:29Z","timestamp":1697000189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.10084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["10.1002\/ccd.10084"],"URL":"https:\/\/doi.org\/10.1002\/ccd.10084","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}