{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:20:56Z","timestamp":1791091256360,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,4,21]],"date-time":"2003-04-21T00:00:00Z","timestamp":1050883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pretreatment with thienopyridines has been shown to improve clinical outcomes in patients undergoing percutaneous coronary intervention (PCI). We determine the impact of angina class on inhibition of platelet aggregation (IPA) following clopidogrel loading. Seventy\u2010two patients (mean age, 64 \u00b1 11 years; 76% male) were pretreated with 450 mg of clopidogrel at least 3 hr prior to PCI. All patients received ASA 325 mg prior to the procedure. Patients were classified into two groups according to angina class: group 1 = stable angina or Braunwald class 1 unstable angina (UA; n = 33); group 2 = Braunwald class 2 or 3 UA (n = 39). IPA was measured prior to PCI, with the Ichor point\u2010of\u2010care platelet analyzer (Helena Laboratories, Beaumont, TX), using 20 \u03bcM of ADP. Group 2 patients were more likely to have prior MI (54% vs. 27%; <jats:italic>P<\/jats:italic> = 0.023), prior CABG (33% vs. 5%; <jats:italic>P<\/jats:italic> = 0.046), and received IV heparin (64% vs. 27%; <jats:italic>P<\/jats:italic> = 0.0018). Mean IPA was significantly lower in group 2 compared to group 1 (19% \u00b1 22% vs. 32% \u00b1 22%; <jats:italic>P<\/jats:italic> = 0.004). In multivariate analysis, higher angina class was independently associated with lower IPA (<jats:italic>P<\/jats:italic> = 0.018). Patients with UA undergoing PCI have a lower IPA following clopidogrel loading with 450 mg. This may indicate the possibility of clopidogrel resistance in such patients. Cathet Cardiovasc Intervent 2003;59:21\u201325. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.10494","type":"journal-article","created":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T17:00:29Z","timestamp":1051203629000},"page":"21-25","source":"Crossref","is-referenced-by-count":74,"title":["Impact of angina class on inhibition of platelet aggregation following clopidogrel loading in patients undergoing coronary intervention: Do we need more aggressive dosing regimens in unstable angina?"],"prefix":"10.1002","volume":"59","author":[{"given":"Daniel","family":"Soffer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issam","family":"Moussa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore J.","family":"Harjai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Boura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon R.","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy L.","family":"Grines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"O'Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary S.","family":"Roubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Moses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,4,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201233260406"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005313222201"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.71.4.699"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.73.3.418"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.6.2728"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a015039"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-199607000-00007"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604253341702"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.16.1597"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812033392303"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.20.2126"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.2.215"},{"issue":"2","key":"e_1_2_6_14_2","first-page":"15","article-title":"Clopidogrel loading dose regimens: kinetic profile of pharmacodynamic response in healthy subjects","volume":"25","author":"Savcic M","year":"1999","journal-title":"Semin Thromb Hemost"},{"issue":"2","key":"e_1_2_6_15_2","first-page":"3","article-title":"Single\u2010dose pharmacodynamics of clopidogrel","volume":"25","author":"Thebault JJ","year":"1999","journal-title":"Semin Thromb Hemost"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.24.2823"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01369-2"},{"key":"e_1_2_6_18_2","first-page":"307A","article-title":"What is the appropriate loading dose of clopidogrel prior to stent implantation? 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